PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 48 | hr | p-mTOR(S2448) | 0.55839 | -0.16851 |
| SKMEL28 | 48 | hr | p-p70S6K(T421/S424) | 0.62969 | -0.23589 |
| SKMEL28 | 48 | hr | p-p70S6K(T389) | 0.42640 | 0.01345 |
| SKMEL28 | 48 | hr | p-S6(S235/236) | 3.21420 | -0.12182 |
| SKMEL28 | 48 | hr | p-AMPK(T172) | -1.91770 | -0.69557 |
| SKMEL28 | 48 | hr | p-JNK(T183/Y185) | -0.42593 | -0.67233 |
| SKMEL28 | 48 | hr | Total c-Jun | -1.04320 | -0.10480 |
| SKMEL28 | 48 | hr | p-cJun(S63) | -1.16340 | -0.39616 |
| SKMEL28 | 48 | hr | p-P38(T180/Y182) | 0.63043 | 0.93016 |
| SKMEL28 | 48 | hr | p-HSP27(S82) | -0.44036 | -0.42333 |
| SKMEL28 | 48 | hr | p-NFKB(S536) | 0.71128 | -0.18884 |
| SKMEL28 | 48 | hr | Bim | -3.11680 | -0.99508 |
| SKMEL28 | 48 | hr | cPARP | -1.34920 | -0.94426 |
| SKMEL28 | 48 | hr | p-Histone H3(S10) | 8.65750 | 1.61730 |
| SKMEL28 | 48 | hr | p27 Kip1 | -3.92110 | -1.28240 |
| WM-115 | 1 | hr | pMEK(S217/221) | 4.70140 | -0.75664 |
| WM-115 | 1 | hr | pERK(T202/Y204) | 9.23570 | -0.49027 |
| WM-115 | 1 | hr | p-p90RSK(S380) | 1.12520 | 0.05266 |
| WM-115 | 1 | hr | p-p90RSK(T573) | 0.43579 | 0.54794 |
| WM-115 | 1 | hr | p-AKT(T308) | 1.66190 | 1.05880 |
| WM-115 | 1 | hr | p-AKT(S473) | 0.69382 | 0.93824 |
| WM-115 | 1 | hr | p-mTOR(S2448) | 0.71520 | 0.72190 |
| WM-115 | 1 | hr | p-p70S6K(T421/S424) | 1.16340 | 0.25295 |
| WM-115 | 1 | hr | p-p70S6K(T389) | 1.42630 | 0.49719 |
| WM-115 | 1 | hr | p-S6(S235/236) | 0.13554 | -0.47737 |