PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 10 | hr | cPARP | 0.96645 | 0.34815 |
| LOXIMVI | 10 | hr | p-Histone H3(S10) | 0.97090 | 0.24712 |
| LOXIMVI | 10 | hr | p27 Kip1 | 0.88263 | -0.17220 |
| LOXIMVI | 24 | hr | pMEK(S217/221) | 0.77258 | -5.57340 |
| LOXIMVI | 24 | hr | pERK(T202/Y204) | 2.46960 | -0.83956 |
| LOXIMVI | 24 | hr | p-p90RSK(S380) | 0.99782 | 0.16290 |
| LOXIMVI | 24 | hr | p-p90RSK(T573) | 0.70491 | 0.13171 |
| LOXIMVI | 24 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 24 | hr | p-AKT(S473) | -0.30402 | 1.02110 |
| LOXIMVI | 24 | hr | p-mTOR(S2448) | 0.53089 | 0.47276 |
| LOXIMVI | 24 | hr | p-p70S6K(T421/S424) | 0.47519 | 1.10270 |
| LOXIMVI | 24 | hr | p-p70S6K(T389) | 1.53590 | 1.05560 |
| LOXIMVI | 24 | hr | p-S6(S235/236) | 2.54140 | -1.37440 |
| LOXIMVI | 24 | hr | p-AMPK(T172) | -0.23340 | 1.06020 |
| LOXIMVI | 24 | hr | p-JNK(T183/Y185) | 0.38400 | 1.04720 |
| LOXIMVI | 24 | hr | Total c-Jun | 1.70990 | -0.35062 |
| LOXIMVI | 24 | hr | p-cJun(S63) | 0.13391 | 0.54488 |
| LOXIMVI | 24 | hr | p-P38(T180/Y182) | 0.63688 | 0.50756 |
| LOXIMVI | 24 | hr | p-HSP27(S82) | 0.36387 | 0.30241 |
| LOXIMVI | 24 | hr | p-NFKB(S536) | 0.16404 | 0.60448 |
| LOXIMVI | 24 | hr | Bim | -0.11516 | 1.54930 |
| LOXIMVI | 24 | hr | cPARP | 0.05244 | 0.85122 |
| LOXIMVI | 24 | hr | p-Histone H3(S10) | 3.39840 | -0.78259 |
| LOXIMVI | 24 | hr | p27 Kip1 | -0.11160 | 0.26765 |
| LOXIMVI | 48 | hr | pMEK(S217/221) | 0.80333 | -6.00350 |