PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 24 | hr | p-p70S6K(T421/S424) | 0.09485 | -0.58913 |
| COLO 858 | 24 | hr | p-p70S6K(T389) | 2.34360 | -0.18622 |
| COLO 858 | 24 | hr | p-S6(S235/236) | 7.59350 | 0.55136 |
| COLO 858 | 24 | hr | p-AMPK(T172) | -0.57698 | -0.62992 |
| COLO 858 | 24 | hr | p-JNK(T183/Y185) | -2.60770 | -0.69431 |
| COLO 858 | 24 | hr | Total c-Jun | -1.56820 | -0.92227 |
| COLO 858 | 24 | hr | p-cJun(S63) | -1.45390 | -0.76056 |
| COLO 858 | 24 | hr | p-P38(T180/Y182) | -0.76429 | 0.82830 |
| COLO 858 | 24 | hr | p-HSP27(S82) | -0.34308 | -0.74685 |
| COLO 858 | 24 | hr | p-NFKB(S536) | 0.85647 | -0.08205 |
| COLO 858 | 24 | hr | Bim | -6.02050 | -1.29730 |
| COLO 858 | 24 | hr | cPARP | -1.87600 | 0.09620 |
| COLO 858 | 24 | hr | p-Histone H3(S10) | 1.50870 | -0.60283 |
| COLO 858 | 24 | hr | p27 Kip1 | -5.50970 | -1.34610 |
| COLO 858 | 48 | hr | pMEK(S217/221) | 5.28110 | 1.10760 |
| COLO 858 | 48 | hr | pERK(T202/Y204) | 7.31020 | -2.40440 |
| COLO 858 | 48 | hr | p-p90RSK(S380) | 1.04080 | -0.16354 |
| COLO 858 | 48 | hr | p-p90RSK(T573) | 1.97630 | -1.06550 |
| COLO 858 | 48 | hr | p-AKT(T308) | 0.54846 | -1.43320 |
| COLO 858 | 48 | hr | p-AKT(S473) | 0.59697 | -1.31170 |
| COLO 858 | 48 | hr | p-mTOR(S2448) | 2.68940 | -1.52560 |
| COLO 858 | 48 | hr | p-p70S6K(T421/S424) | 3.94250 | -1.28780 |
| COLO 858 | 48 | hr | p-p70S6K(T389) | -0.08778 | 0.23806 |
| COLO 858 | 48 | hr | p-S6(S235/236) | 7.78010 | -0.48481 |
| COLO 858 | 48 | hr | p-AMPK(T172) | 0.53849 | 0.00662 |