Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| MK2206 | AU565 | 10.0 | nM | 6 | hr | 318.99 | 83.12 | p-S6 | 233.34 | |
| MK2206 | AU565 | 10.0 | nM | 24 | hr | 370.13 | 117.68 | p-S6 | 503.51 | |
| Triciribine | AU565 | 10.0 | nM | 6 | hr | 305.78 | 80.18 | p-S6 | 222.12 | |
| Triciribine | AU565 | 10.0 | nM | 24 | hr | 493.92 | 126.42 | p-S6 | 481.11 | |
| Dactolisib | AU565 | 10.0 | nM | 6 | hr | 254.25 | 60.00 | p-S6 | 30.27 | |
| Dactolisib | AU565 | 10.0 | nM | 24 | hr | 455.18 | 96.67 | p-S6 | 74.99 | |
| Gefitinib | HCC1954 | 10.0 | nM | 6 | hr | 341.70 | 78.25 | p-S6 | 191.46 | |
| Gefitinib | HCC1954 | 10.0 | nM | 24 | hr | 272.45 | 123.68 | p-S6 | 327.09 | |
| Torkinib | HCC1954 | 1.78 | nM | 6 | hr | 225.32 | 53.82 | p-S6 | 109.00 | |
| Torkinib | HCC1954 | 1.78 | nM | 24 | hr | 262.09 | 105.21 | p-S6 | 373.24 | |
| GSK1059615 | HCC1954 | 10.0 | nM | 6 | hr | 497.92 | 100.21 | p-S6 | 442.56 | |
| GSK1059615 | HCC1954 | 10.0 | nM | 24 | hr | 299.31 | 118.37 | p-S6 | 322.52 | |
| MK2206 | HCC1954 | 10.0 | nM | 6 | hr | 303.44 | 88.14 | p-S6 | 429.68 | |
| MK2206 | HCC1954 | 10.0 | nM | 24 | hr | 284.60 | 117.66 | p-S6 | 295.65 | |
| Triciribine | HCC1954 | 10.0 | nM | 6 | hr | 179.91 | 59.32 | p-S6 | 155.18 | |
| Triciribine | HCC1954 | 10.0 | nM | 24 | hr | 292.05 | 110.86 | p-S6 | 291.89 | |
| Dactolisib | HCC1954 | 10.0 | nM | 6 | hr | 218.87 | 79.18 | p-S6 | 19.17 | |
| Dactolisib | HCC1954 | 10.0 | nM | 24 | hr | 325.84 | 106.21 | p-S6 | 44.17 | |
| Gefitinib | MCF 10A | 10.0 | nM | 6 | hr | 400.06 | 177.82 | p-S6 | 554.57 | |
| Gefitinib | MCF 10A | 10.0 | nM | 24 | hr | 413.04 | 188.00 | p-S6 | 584.31 | |
| Torkinib | MCF 10A | 1.78 | nM | 6 | hr | 479.13 | 181.71 | p-S6 | 769.25 | |
| Torkinib | MCF 10A | 1.78 | nM | 24 | hr | 448.86 | 174.96 | p-S6 | 526.21 | |
| GSK1059615 | MCF 10A | 10.0 | nM | 6 | hr | 453.23 | 198.94 | p-S6 | 918.10 | |
| GSK1059615 | MCF 10A | 10.0 | nM | 24 | hr | 439.77 | 171.32 | p-S6 | 481.95 | |
| MK2206 | MCF 10A | 10.0 | nM | 6 | hr | 378.43 | 163.08 | p-S6 | 558.71 | |