HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
MK2206	MCF 10A	10.0	nM	24	hr	283.43	147.29	p-S6	272.02
Triciribine	MCF 10A	10.0	nM	6	hr	379.91	163.67	p-S6	558.18
Triciribine	MCF 10A	10.0	nM	24	hr	274.81	138.42	p-S6	279.32
Dactolisib	MCF 10A	10.0	nM	6	hr	384.28	149.95	p-S6	617.51
Dactolisib	MCF 10A	10.0	nM	24	hr	309.92	145.81	p-S6	338.14
Gefitinib	T47D	10.0	nM	6	hr	188.40	102.12	p-S6	456.66
Gefitinib	T47D	10.0	nM	24	hr	161.09	111.69	p-S6	351.96
Torkinib	T47D	1.78	nM	6	hr	174.66	100.50	p-S6	491.58
Torkinib	T47D	1.78	nM	24	hr	169.46	100.37	p-S6	336.69
GSK1059615	T47D	10.0	nM	6	hr	169.66	95.69	p-S6	488.48
GSK1059615	T47D	10.0	nM	24	hr	146.83	98.14	p-S6	349.69
MK2206	T47D	10.0	nM	6	hr	97.54	39.59	p-S6	43.82
MK2206	T47D	10.0	nM	24	hr	144.26	97.53	p-S6	375.85
Triciribine	T47D	10.0	nM	6	hr	108.22	62.14	p-S6	86.35
Triciribine	T47D	10.0	nM	24	hr	152.32	96.01	p-S6	376.01
Dactolisib	T47D	10.0	nM	6	hr	109.71	59.02	p-S6	34.49
Dactolisib	T47D	10.0	nM	24	hr	130.33	99.36	p-S6	195.23
Gefitinib	AU565	31.6	nM	6	hr	286.70	67.72	p-S6	146.86
Gefitinib	AU565	31.6	nM	24	hr	516.40	118.08	p-S6	519.88
Torkinib	AU565	7.5	nM	6	hr	233.16	44.97	p-S6	27.34
Torkinib	AU565	7.5	nM	24	hr	415.91	89.31	p-S6	194.93
GSK1059615	AU565	31.6	nM	6	hr	357.60	84.64	p-S6	227.00
GSK1059615	AU565	31.6	nM	24	hr	433.97	109.78	p-S6	476.39
MK2206	AU565	31.6	nM	6	hr	342.27	81.34	p-S6	213.56
MK2206	AU565	31.6	nM	24	hr	359.57	111.63	p-S6	433.19

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