Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | AU565 | 0 (control) | 6 | hr | 286.03 | 62.73 | p-Akt | 29.07 | | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 659.08 | 130.41 | p-Akt | 134.35 | | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 228.66 | 55.93 | p-Akt | 26.38 | | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 522.19 | 120.45 | p-Akt | 94.97 | | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 264.31 | 61.82 | p-Akt | 28.75 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 452.11 | 110.23 | p-Akt | 88.09 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 215.16 | 63.34 | p-Akt | 22.81 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 427.04 | 124.23 | p-Akt | 78.88 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 231.71 | 61.01 | p-Akt | 21.54 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 511.74 | 118.54 | p-Akt | 102.35 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 235.49 | 54.01 | p-Akt | 23.90 | | |
| Dactolisib | AU565 | 0 (control) | 24 | hr | 496.14 | 121.03 | p-Akt | 137.91 | | |
| Gefitinib | HCC1954 | 0 (control) | 6 | hr | 411.80 | 93.54 | p-Akt | 46.61 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 342.49 | 120.54 | p-Akt | 84.26 | | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 182.67 | 40.88 | p-Akt | 23.74 | | |
| Torkinib | HCC1954 | 0 (control) | 24 | hr | 309.60 | 109.35 | p-Akt | 76.75 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 241.24 | 67.17 | p-Akt | 30.76 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 302.50 | 106.62 | p-Akt | 73.55 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 271.78 | 84.99 | p-Akt | 42.06 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 288.09 | 111.00 | p-Akt | 78.02 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 225.27 | 70.45 | p-Akt | 36.85 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 282.25 | 98.69 | p-Akt | 60.55 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 262.96 | 93.99 | p-Akt | 56.53 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 357.28 | 117.27 | p-Akt | 79.92 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 488.10 | 165.19 | p-Akt | 54.11 | |