Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | HCC1954 | 3.16 | uM | 6 | hr | 326.20 | 67.08 | p-S6 | 10.98 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 24 | hr | 302.00 | 67.90 | p-S6 | 11.86 | |
| MK2206 | HCC1954 | 3.16 | uM | 6 | hr | 229.79 | 66.67 | p-S6 | 157.17 | |
| MK2206 | HCC1954 | 3.16 | uM | 24 | hr | 305.44 | 91.08 | p-S6 | 283.49 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 214.06 | 73.06 | p-S6 | 229.86 | |
| Triciribine | HCC1954 | 3.16 | uM | 24 | hr | 258.61 | 95.85 | p-S6 | 355.75 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 251.88 | 74.73 | p-S6 | 18.24 | |
| Dactolisib | HCC1954 | 3.16 | uM | 24 | hr | 263.34 | 59.47 | p-S6 | 8.47 | |
| Gefitinib | MCF 10A | 3.16 | uM | 6 | hr | 196.68 | 148.61 | p-S6 | 437.61 | |
| Gefitinib | MCF 10A | 3.16 | uM | 24 | hr | 199.19 | 32.43 | p-S6 | 54.29 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 625.54 | 171.57 | p-S6 | 556.27 | |
| Torkinib | MCF 10A | 2.37 | uM | 24 | hr | 557.47 | 88.94 | p-S6 | 320.73 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 252.13 | 124.95 | p-S6 | 12.57 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 239.08 | 117.67 | p-S6 | 12.24 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 374.51 | 155.85 | p-S6 | 642.84 | |
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 366.22 | 144.25 | p-S6 | 433.13 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 375.49 | 156.80 | p-S6 | 644.30 | |
| Triciribine | MCF 10A | 3.16 | uM | 24 | hr | 346.00 | 133.89 | p-S6 | 462.17 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 309.72 | 128.64 | p-S6 | 394.08 | |
| Dactolisib | MCF 10A | 3.16 | uM | 24 | hr | 420.04 | 69.15 | p-S6 | 259.56 | |
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 166.54 | 105.20 | p-S6 | 470.44 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 140.35 | 98.30 | p-S6 | 362.29 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 150.77 | 71.12 | p-S6 | 5.80 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 118.48 | 37.34 | p-S6 | 4.86 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 155.38 | 59.43 | p-S6 | 5.70 | |