HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
GSK1059615	MCF 10A	3.16	nM	24	hr	455.51	172.86	p-S6	451.67
MK2206	MCF 10A	3.16	nM	6	hr	387.67	155.66	p-S6	537.91
MK2206	MCF 10A	3.16	nM	24	hr	306.79	149.19	p-S6	277.89
Triciribine	MCF 10A	3.16	nM	6	hr	389.81	156.34	p-S6	538.30
Triciribine	MCF 10A	3.16	nM	24	hr	323.11	127.51	p-S6	322.66
Dactolisib	MCF 10A	3.16	nM	6	hr	371.03	152.85	p-S6	587.69
Dactolisib	MCF 10A	3.16	nM	24	hr	298.11	144.88	p-S6	297.75
Gefitinib	T47D	3.16	nM	6	hr	176.59	102.38	p-S6	438.72
Gefitinib	T47D	3.16	nM	24	hr	151.34	109.80	p-S6	329.92
Torkinib	T47D	0.422	nM	6	hr	165.94	93.69	p-S6	481.06
Torkinib	T47D	0.422	nM	24	hr	159.48	99.77	p-S6	344.68
GSK1059615	T47D	3.16	nM	6	hr	157.36	92.05	p-S6	478.47
GSK1059615	T47D	3.16	nM	24	hr	148.66	95.11	p-S6	340.27
MK2206	T47D	3.16	nM	6	hr	93.03	33.88	p-S6	37.58
MK2206	T47D	3.16	nM	24	hr	139.77	99.87	p-S6	356.63
Triciribine	T47D	3.16	nM	6	hr	100.11	49.21	p-S6	54.89
Triciribine	T47D	3.16	nM	24	hr	145.80	98.73	p-S6	357.34
Dactolisib	T47D	3.16	nM	6	hr	88.78	28.61	p-S6	40.04
Dactolisib	T47D	3.16	nM	24	hr	131.38	94.63	p-S6	269.12
Gefitinib	AU565	10.0	nM	6	hr	257.60	59.37	p-S6	139.49
Gefitinib	AU565	10.0	nM	24	hr	538.95	126.63	p-S6	523.20
Torkinib	AU565	1.78	nM	6	hr	392.82	70.12	p-S6	168.23
Torkinib	AU565	1.78	nM	24	hr	457.35	107.85	p-S6	384.28
GSK1059615	AU565	10.0	nM	6	hr	390.90	86.67	p-S6	285.82
GSK1059615	AU565	10.0	nM	24	hr	415.26	106.11	p-S6	477.61

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