Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 316.0 | nM | 24 | hr | 113.46 | 38.99 | p-Akt | 14.57 | |
| Gefitinib | AU565 | 1.0 | uM | 6 | hr | 281.51 | 66.62 | p-Akt | 23.00 | |
| Gefitinib | AU565 | 1.0 | uM | 24 | hr | 381.82 | 84.05 | p-Akt | 79.75 | |
| Torkinib | AU565 | 562.0 | nM | 6 | hr | 337.64 | 57.59 | p-Akt | 14.16 | |
| Torkinib | AU565 | 562.0 | nM | 24 | hr | 393.59 | 59.89 | p-Akt | 21.37 | |
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 325.32 | 65.35 | p-Akt | 24.33 | |
| GSK1059615 | AU565 | 1.0 | uM | 24 | hr | 460.35 | 72.86 | p-Akt | 28.61 | |
| MK2206 | AU565 | 1.0 | uM | 6 | hr | 368.63 | 75.60 | p-Akt | 17.45 | |
| MK2206 | AU565 | 1.0 | uM | 24 | hr | 359.12 | 71.98 | p-Akt | 20.13 | |
| Triciribine | AU565 | 1.0 | uM | 6 | hr | 326.60 | 72.81 | p-Akt | 21.21 | |
| Triciribine | AU565 | 1.0 | uM | 24 | hr | 508.25 | 83.72 | p-Akt | 40.60 | |
| Dactolisib | AU565 | 1.0 | uM | 6 | hr | 250.79 | 51.61 | p-Akt | 14.99 | |
| Dactolisib | AU565 | 1.0 | uM | 24 | hr | 446.03 | 61.70 | p-Akt | 20.91 | |
| Gefitinib | HCC1954 | 1.0 | uM | 6 | hr | 159.81 | 59.51 | p-Akt | 23.63 | |
| Gefitinib | HCC1954 | 1.0 | uM | 24 | hr | 254.11 | 92.32 | p-Akt | 65.87 | |
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 242.75 | 60.54 | p-Akt | 14.19 | |
| Torkinib | HCC1954 | 562.0 | nM | 24 | hr | 239.91 | 70.30 | p-Akt | 17.84 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 6 | hr | 466.89 | 78.65 | p-Akt | 26.79 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 24 | hr | 302.84 | 57.11 | p-Akt | 18.91 | |
| MK2206 | HCC1954 | 1.0 | uM | 6 | hr | 311.04 | 76.80 | p-Akt | 17.06 | |
| MK2206 | HCC1954 | 1.0 | uM | 24 | hr | 259.01 | 88.81 | p-Akt | 19.76 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 272.11 | 87.04 | p-Akt | 32.04 | |
| Triciribine | HCC1954 | 1.0 | uM | 24 | hr | 245.06 | 92.53 | p-Akt | 28.75 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 209.83 | 60.36 | p-Akt | 16.60 | |
| Dactolisib | HCC1954 | 1.0 | uM | 24 | hr | 266.78 | 61.07 | p-Akt | 16.68 | |