Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 193.59 | 49.84 | p-Akt | 12.54 | |
| Dactolisib | HCC1954 | 316.0 | nM | 24 | hr | 257.79 | 66.04 | p-Akt | 17.13 | |
| Gefitinib | MCF 10A | 316.0 | nM | 6 | hr | 207.85 | 153.83 | p-Akt | 28.02 | |
| Gefitinib | MCF 10A | 316.0 | nM | 24 | hr | 253.55 | 151.61 | p-Akt | 27.91 | |
| Torkinib | MCF 10A | 133.0 | nM | 6 | hr | 514.18 | 149.25 | p-Akt | 23.73 | |
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 430.94 | 141.09 | p-Akt | 16.66 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 6 | hr | 282.17 | 153.01 | p-Akt | 21.36 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 24 | hr | 269.35 | 140.01 | p-Akt | 16.45 | |
| MK2206 | MCF 10A | 316.0 | nM | 6 | hr | 384.18 | 147.34 | p-Akt | 20.10 | |
| MK2206 | MCF 10A | 316.0 | nM | 24 | hr | 298.46 | 154.22 | p-Akt | 17.37 | |
| Triciribine | MCF 10A | 316.0 | nM | 6 | hr | 386.31 | 147.84 | p-Akt | 20.14 | |
| Triciribine | MCF 10A | 316.0 | nM | 24 | hr | 227.23 | 137.91 | p-Akt | 15.66 | |
| Dactolisib | MCF 10A | 316.0 | nM | 6 | hr | 344.98 | 116.76 | p-Akt | 17.28 | |
| Dactolisib | MCF 10A | 316.0 | nM | 24 | hr | 291.15 | 48.65 | p-Akt | 11.63 | |
| Gefitinib | T47D | 316.0 | nM | 6 | hr | 170.40 | 93.13 | p-Akt | 99.63 | |
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 144.02 | 94.73 | p-Akt | 70.89 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 159.02 | 71.09 | p-Akt | 22.14 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 125.69 | 38.17 | p-Akt | 18.38 | |
| GSK1059615 | T47D | 316.0 | nM | 6 | hr | 152.86 | 67.21 | p-Akt | 38.54 | |
| GSK1059615 | T47D | 316.0 | nM | 24 | hr | 144.36 | 44.01 | p-Akt | 26.65 | |
| MK2206 | T47D | 316.0 | nM | 6 | hr | 97.94 | 33.78 | p-Akt | 6.19 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 138.70 | 57.11 | p-Akt | 16.15 | |
| Triciribine | T47D | 316.0 | nM | 6 | hr | 99.80 | 36.99 | p-Akt | 9.71 | |
| Triciribine | T47D | 316.0 | nM | 24 | hr | 166.67 | 72.06 | p-Akt | 37.58 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 88.99 | 42.86 | p-Akt | 6.47 | |