Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | T47D | 100.0 | nM | 24 | hr | 171.25 | 79.24 | p-Akt | 41.68 | |
| Dactolisib | T47D | 100.0 | nM | 6 | hr | 84.56 | 34.41 | p-Akt | 6.52 | |
| Dactolisib | T47D | 100.0 | nM | 24 | hr | 109.86 | 40.91 | p-Akt | 18.28 | |
| Gefitinib | AU565 | 316.0 | nM | 6 | hr | 228.71 | 57.03 | p-Akt | 21.72 | |
| Gefitinib | AU565 | 316.0 | nM | 24 | hr | 455.36 | 96.01 | p-Akt | 108.37 | |
| Torkinib | AU565 | 133.0 | nM | 6 | hr | 385.95 | 63.98 | p-Akt | 16.41 | |
| Torkinib | AU565 | 133.0 | nM | 24 | hr | 379.56 | 63.49 | p-Akt | 23.33 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 331.92 | 66.44 | p-Akt | 28.81 | |
| GSK1059615 | AU565 | 316.0 | nM | 24 | hr | 509.13 | 83.17 | p-Akt | 50.75 | |
| MK2206 | AU565 | 316.0 | nM | 6 | hr | 363.52 | 69.11 | p-Akt | 16.75 | |
| MK2206 | AU565 | 316.0 | nM | 24 | hr | 365.78 | 79.62 | p-Akt | 23.37 | |
| Triciribine | AU565 | 316.0 | nM | 6 | hr | 257.75 | 64.29 | p-Akt | 17.36 | |
| Triciribine | AU565 | 316.0 | nM | 24 | hr | 543.33 | 92.26 | p-Akt | 47.64 | |
| Dactolisib | AU565 | 316.0 | nM | 6 | hr | 260.52 | 52.61 | p-Akt | 14.55 | |
| Dactolisib | AU565 | 316.0 | nM | 24 | hr | 445.48 | 61.89 | p-Akt | 21.06 | |
| Gefitinib | HCC1954 | 316.0 | nM | 6 | hr | 126.23 | 35.22 | p-Akt | 18.96 | |
| Gefitinib | HCC1954 | 316.0 | nM | 24 | hr | 269.25 | 102.68 | p-Akt | 71.62 | |
| Torkinib | HCC1954 | 133.0 | nM | 6 | hr | 233.30 | 56.33 | p-Akt | 14.65 | |
| Torkinib | HCC1954 | 133.0 | nM | 24 | hr | 249.68 | 78.36 | p-Akt | 26.29 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 6 | hr | 425.79 | 89.74 | p-Akt | 33.33 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 24 | hr | 313.57 | 66.74 | p-Akt | 22.92 | |
| MK2206 | HCC1954 | 316.0 | nM | 6 | hr | 269.60 | 75.06 | p-Akt | 15.96 | |
| MK2206 | HCC1954 | 316.0 | nM | 24 | hr | 278.37 | 99.86 | p-Akt | 21.27 | |
| Triciribine | HCC1954 | 316.0 | nM | 6 | hr | 258.48 | 83.20 | p-Akt | 30.56 | |
| Triciribine | HCC1954 | 316.0 | nM | 24 | hr | 253.47 | 94.43 | p-Akt | 30.71 | |