HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Gefitinib	T47D	1.0	nM	24	hr	169.83	103.51	p-Akt	76.42
Torkinib	T47D	0.1	nM	6	hr	177.18	86.32	p-Akt	86.42
Torkinib	T47D	0.1	nM	24	hr	170.63	99.96	p-Akt	65.73
GSK1059615	T47D	1.0	nM	6	hr	163.85	87.64	p-Akt	92.36
GSK1059615	T47D	1.0	nM	24	hr	156.20	90.59	p-Akt	63.43
MK2206	T47D	1.0	nM	6	hr	96.05	33.89	p-Akt	12.65
MK2206	T47D	1.0	nM	24	hr	178.24	100.47	p-Akt	57.48
Triciribine	T47D	1.0	nM	6	hr	102.04	43.09	p-Akt	16.40
Triciribine	T47D	1.0	nM	24	hr	163.02	95.08	p-Akt	67.15
Dactolisib	T47D	1.0	nM	6	hr	92.92	41.52	p-Akt	14.33
Dactolisib	T47D	1.0	nM	24	hr	151.06	89.06	p-Akt	44.96
Gefitinib	AU565	3.16	nM	6	hr	286.12	61.91	p-Akt	30.06
Gefitinib	AU565	3.16	nM	24	hr	587.36	122.21	p-Akt	149.72
Torkinib	AU565	0.422	nM	6	hr	323.79	66.32	p-Akt	30.57
Torkinib	AU565	0.422	nM	24	hr	486.69	109.36	p-Akt	78.15
GSK1059615	AU565	3.16	nM	6	hr	343.13	84.72	p-Akt	37.38
GSK1059615	AU565	3.16	nM	24	hr	452.66	116.02	p-Akt	85.08
MK2206	AU565	3.16	nM	6	hr	292.99	75.06	p-Akt	24.55
MK2206	AU565	3.16	nM	24	hr	426.53	118.40	p-Akt	63.78
Triciribine	AU565	3.16	nM	6	hr	325.43	81.06	p-Akt	26.26
Triciribine	AU565	3.16	nM	24	hr	528.92	125.83	p-Akt	107.96
Dactolisib	AU565	3.16	nM	6	hr	249.08	56.47	p-Akt	21.82
Dactolisib	AU565	3.16	nM	24	hr	507.93	108.62	p-Akt	101.35
Gefitinib	HCC1954	3.16	nM	6	hr	192.10	43.07	p-Akt	19.92
Gefitinib	HCC1954	3.16	nM	24	hr	289.95	126.36	p-Akt	82.40

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