Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC1954 | 0.422 | nM | 6 | hr | 257.64 | 55.79 | p-Akt | 25.11 | |
| Torkinib | HCC1954 | 0.422 | nM | 24 | hr | 286.30 | 107.38 | p-Akt | 59.03 | |
| GSK1059615 | HCC1954 | 3.16 | nM | 6 | hr | 508.86 | 99.25 | p-Akt | 61.87 | |
| GSK1059615 | HCC1954 | 3.16 | nM | 24 | hr | 318.88 | 109.27 | p-Akt | 69.77 | |
| MK2206 | HCC1954 | 3.16 | nM | 6 | hr | 283.02 | 85.05 | p-Akt | 33.50 | |
| MK2206 | HCC1954 | 3.16 | nM | 24 | hr | 297.41 | 116.46 | p-Akt | 57.90 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 247.28 | 82.46 | p-Akt | 41.77 | |
| Triciribine | HCC1954 | 3.16 | nM | 24 | hr | 305.07 | 109.15 | p-Akt | 57.57 | |
| Dactolisib | HCC1954 | 3.16 | nM | 6 | hr | 182.51 | 40.62 | p-Akt | 20.25 | |
| Dactolisib | HCC1954 | 3.16 | nM | 24 | hr | 277.21 | 100.98 | p-Akt | 71.52 | |
| Gefitinib | MCF 10A | 3.16 | nM | 6 | hr | 404.76 | 165.56 | p-Akt | 42.14 | |
| Gefitinib | MCF 10A | 3.16 | nM | 24 | hr | 320.67 | 141.23 | p-Akt | 42.95 | |
| Torkinib | MCF 10A | 0.422 | nM | 6 | hr | 475.26 | 169.60 | p-Akt | 43.49 | |
| Torkinib | MCF 10A | 0.422 | nM | 24 | hr | 365.79 | 140.07 | p-Akt | 43.54 | |
| GSK1059615 | MCF 10A | 3.16 | nM | 6 | hr | 423.39 | 173.44 | p-Akt | 43.10 | |
| GSK1059615 | MCF 10A | 3.16 | nM | 24 | hr | 295.07 | 128.13 | p-Akt | 36.06 | |
| MK2206 | MCF 10A | 3.16 | nM | 6 | hr | 367.98 | 149.68 | p-Akt | 38.17 | |
| MK2206 | MCF 10A | 3.16 | nM | 24 | hr | 261.70 | 136.39 | p-Akt | 33.76 | |
| Triciribine | MCF 10A | 3.16 | nM | 6 | hr | 369.63 | 150.94 | p-Akt | 38.31 | |
| Triciribine | MCF 10A | 3.16 | nM | 24 | hr | 240.51 | 127.13 | p-Akt | 30.95 | |
| Dactolisib | MCF 10A | 3.16 | nM | 6 | hr | 341.01 | 143.37 | p-Akt | 32.48 | |
| Dactolisib | MCF 10A | 3.16 | nM | 24 | hr | 238.10 | 132.70 | p-Akt | 28.38 | |
| Gefitinib | T47D | 3.16 | nM | 6 | hr | 175.01 | 94.61 | p-Akt | 101.23 | |
| Gefitinib | T47D | 3.16 | nM | 24 | hr | 161.75 | 107.53 | p-Akt | 77.43 | |
| Torkinib | T47D | 0.422 | nM | 6 | hr | 176.07 | 86.72 | p-Akt | 75.19 | |