HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Torkinib	T47D	0.422	nM	24	hr	158.96	96.96	p-Akt	55.13
GSK1059615	T47D	3.16	nM	6	hr	184.41	88.09	p-Akt	94.58
GSK1059615	T47D	3.16	nM	24	hr	160.94	91.56	p-Akt	64.77
MK2206	T47D	3.16	nM	6	hr	94.76	36.38	p-Akt	11.53
MK2206	T47D	3.16	nM	24	hr	165.97	97.23	p-Akt	50.67
Triciribine	T47D	3.16	nM	6	hr	99.80	56.12	p-Akt	19.64
Triciribine	T47D	3.16	nM	24	hr	155.67	91.70	p-Akt	61.29
Dactolisib	T47D	3.16	nM	6	hr	101.85	62.11	p-Akt	17.35
Dactolisib	T47D	3.16	nM	24	hr	149.56	95.04	p-Akt	40.60
Gefitinib	AU565	10.0	nM	6	hr	313.57	67.91	p-Akt	32.33
Gefitinib	AU565	10.0	nM	24	hr	588.35	123.02	p-Akt	145.47
Torkinib	AU565	1.78	nM	6	hr	268.73	51.04	p-Akt	19.40
Torkinib	AU565	1.78	nM	24	hr	469.76	104.61	p-Akt	74.05
GSK1059615	AU565	10.0	nM	6	hr	392.75	84.73	p-Akt	40.60
GSK1059615	AU565	10.0	nM	24	hr	474.17	114.89	p-Akt	84.77
MK2206	AU565	10.0	nM	6	hr	400.16	81.54	p-Akt	34.73
MK2206	AU565	10.0	nM	24	hr	408.17	116.09	p-Akt	54.77
Triciribine	AU565	10.0	nM	6	hr	253.31	66.34	p-Akt	19.84
Triciribine	AU565	10.0	nM	24	hr	534.07	122.93	p-Akt	101.43
Dactolisib	AU565	10.0	nM	6	hr	261.82	58.53	p-Akt	20.86
Dactolisib	AU565	10.0	nM	24	hr	502.62	93.94	p-Akt	79.66
Gefitinib	HCC1954	10.0	nM	6	hr	313.80	78.00	p-Akt	32.80
Gefitinib	HCC1954	10.0	nM	24	hr	309.05	123.62	p-Akt	79.39
Torkinib	HCC1954	1.78	nM	6	hr	242.69	61.93	p-Akt	24.56
Torkinib	HCC1954	1.78	nM	24	hr	275.43	109.55	p-Akt	57.56

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