Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | MCF 10A | 1.0 | uM | 24 | hr | 294.08 | 95.49 | p-S6 | 31.31 | |
| MK2206 | MCF 10A | 1.0 | uM | 6 | hr | 384.14 | 152.08 | p-S6 | 495.57 | |
| MK2206 | MCF 10A | 1.0 | uM | 24 | hr | 342.08 | 163.56 | p-S6 | 325.28 | |
| Triciribine | MCF 10A | 1.0 | uM | 6 | hr | 386.49 | 153.46 | p-S6 | 499.49 | |
| Triciribine | MCF 10A | 1.0 | uM | 24 | hr | 244.05 | 150.16 | p-S6 | 234.10 | |
| Dactolisib | MCF 10A | 1.0 | uM | 6 | hr | 303.98 | 122.00 | p-S6 | 364.62 | |
| Dactolisib | MCF 10A | 1.0 | uM | 24 | hr | 362.01 | 50.60 | p-S6 | 217.65 | |
| Gefitinib | T47D | 1.0 | uM | 6 | hr | 162.98 | 106.81 | p-S6 | 490.55 | |
| Gefitinib | T47D | 1.0 | uM | 24 | hr | 147.84 | 107.65 | p-S6 | 345.82 | |
| Torkinib | T47D | 562.0 | nM | 6 | hr | 150.96 | 72.90 | p-S6 | 6.30 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 120.85 | 41.75 | p-S6 | 5.37 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 178.56 | 69.11 | p-S6 | 6.78 | |
| GSK1059615 | T47D | 1.0 | uM | 24 | hr | 157.48 | 47.97 | p-S6 | 6.29 | |
| MK2206 | T47D | 1.0 | uM | 6 | hr | 114.25 | 43.77 | p-S6 | 32.03 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 152.27 | 69.95 | p-S6 | 79.39 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 121.20 | 71.28 | p-S6 | 120.93 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 178.41 | 84.59 | p-S6 | 460.89 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 89.72 | 38.09 | p-S6 | 3.89 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 108.89 | 34.29 | p-S6 | 4.77 | |
| Gefitinib | AU565 | 3.16 | uM | 6 | hr | 194.79 | 43.73 | p-S6 | 15.66 | |
| Gefitinib | AU565 | 3.16 | uM | 24 | hr | 339.51 | 77.68 | p-S6 | 68.99 | |
| Torkinib | AU565 | 2.37 | uM | 6 | hr | 223.07 | 39.30 | p-S6 | 10.42 | |
| Torkinib | AU565 | 2.37 | uM | 24 | hr | 402.39 | 62.56 | p-S6 | 9.78 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 229.36 | 49.67 | p-S6 | 8.09 | |
| GSK1059615 | AU565 | 3.16 | uM | 24 | hr | 351.38 | 73.63 | p-S6 | 9.93 | |