Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 237.78 | 52.90 | p-S6 | 9.57 | |
| GSK1059615 | AU565 | 1.0 | uM | 24 | hr | 455.83 | 72.74 | p-S6 | 22.95 | |
| MK2206 | AU565 | 1.0 | uM | 6 | hr | 291.42 | 63.83 | p-S6 | 65.88 | |
| MK2206 | AU565 | 1.0 | uM | 24 | hr | 375.03 | 77.36 | p-S6 | 146.03 | |
| Triciribine | AU565 | 1.0 | uM | 6 | hr | 355.24 | 89.01 | p-S6 | 217.14 | |
| Triciribine | AU565 | 1.0 | uM | 24 | hr | 521.46 | 92.88 | p-S6 | 273.09 | |
| Dactolisib | AU565 | 1.0 | uM | 6 | hr | 218.19 | 44.53 | p-S6 | 12.18 | |
| Dactolisib | AU565 | 1.0 | uM | 24 | hr | 442.86 | 59.90 | p-S6 | 12.23 | |
| Gefitinib | HCC1954 | 1.0 | uM | 6 | hr | 163.03 | 55.69 | p-S6 | 102.42 | |
| Gefitinib | HCC1954 | 1.0 | uM | 24 | hr | 265.05 | 96.34 | p-S6 | 320.53 | |
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 146.89 | 24.95 | p-S6 | 10.19 | |
| Torkinib | HCC1954 | 562.0 | nM | 24 | hr | 245.07 | 75.47 | p-S6 | 11.19 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 6 | hr | 383.68 | 75.62 | p-S6 | 8.35 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 24 | hr | 288.17 | 55.90 | p-S6 | 7.24 | |
| MK2206 | HCC1954 | 1.0 | uM | 6 | hr | 294.27 | 79.87 | p-S6 | 395.73 | |
| MK2206 | HCC1954 | 1.0 | uM | 24 | hr | 287.45 | 104.17 | p-S6 | 373.72 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 283.58 | 95.51 | p-S6 | 590.30 | |
| Triciribine | HCC1954 | 1.0 | uM | 24 | hr | 240.59 | 101.48 | p-S6 | 325.74 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 207.47 | 62.19 | p-S6 | 11.17 | |
| Dactolisib | HCC1954 | 1.0 | uM | 24 | hr | 276.43 | 60.95 | p-S6 | 11.55 | |
| Gefitinib | MCF 10A | 1.0 | uM | 6 | hr | 169.18 | 149.72 | p-S6 | 409.53 | |
| Gefitinib | MCF 10A | 1.0 | uM | 24 | hr | 195.98 | 72.13 | p-S6 | 352.09 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 543.48 | 156.73 | p-S6 | 529.47 | |
| Torkinib | MCF 10A | 562.0 | nM | 24 | hr | 475.34 | 106.15 | p-S6 | 359.84 | |
| GSK1059615 | MCF 10A | 1.0 | uM | 6 | hr | 250.89 | 136.71 | p-S6 | 57.24 | |