Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 485.32 | 164.64 | p-S6 | 505.42 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 6 | hr | 293.57 | 165.75 | p-S6 | 345.88 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 24 | hr | 306.73 | 152.32 | p-S6 | 257.52 | |
| MK2206 | MCF 10A | 316.0 | nM | 6 | hr | 402.65 | 157.16 | p-S6 | 488.56 | |
| MK2206 | MCF 10A | 316.0 | nM | 24 | hr | 287.84 | 160.35 | p-S6 | 267.15 | |
| Triciribine | MCF 10A | 316.0 | nM | 6 | hr | 405.80 | 158.51 | p-S6 | 492.45 | |
| Triciribine | MCF 10A | 316.0 | nM | 24 | hr | 235.13 | 150.80 | p-S6 | 216.81 | |
| Dactolisib | MCF 10A | 316.0 | nM | 6 | hr | 360.93 | 123.35 | p-S6 | 338.83 | |
| Dactolisib | MCF 10A | 316.0 | nM | 24 | hr | 332.74 | 49.60 | p-S6 | 216.41 | |
| Gefitinib | T47D | 316.0 | nM | 6 | hr | 169.95 | 110.41 | p-S6 | 492.09 | |
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 146.68 | 117.39 | p-S6 | 365.01 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 157.46 | 75.31 | p-S6 | 5.95 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 119.60 | 41.42 | p-S6 | 5.06 | |
| GSK1059615 | T47D | 316.0 | nM | 6 | hr | 165.06 | 78.53 | p-S6 | 39.67 | |
| GSK1059615 | T47D | 316.0 | nM | 24 | hr | 141.77 | 44.53 | p-S6 | 9.54 | |
| MK2206 | T47D | 316.0 | nM | 6 | hr | 110.20 | 48.08 | p-S6 | 40.07 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 144.25 | 90.81 | p-S6 | 291.15 | |
| Triciribine | T47D | 316.0 | nM | 6 | hr | 119.23 | 59.88 | p-S6 | 87.34 | |
| Triciribine | T47D | 316.0 | nM | 24 | hr | 172.69 | 87.09 | p-S6 | 445.42 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 97.87 | 46.75 | p-S6 | 4.38 | |
| Dactolisib | T47D | 316.0 | nM | 24 | hr | 109.12 | 37.01 | p-S6 | 5.01 | |
| Gefitinib | AU565 | 1.0 | uM | 6 | hr | 215.97 | 50.77 | p-S6 | 32.49 | |
| Gefitinib | AU565 | 1.0 | uM | 24 | hr | 361.65 | 88.03 | p-S6 | 303.58 | |
| Torkinib | AU565 | 562.0 | nM | 6 | hr | 222.08 | 39.55 | p-S6 | 11.30 | |
| Torkinib | AU565 | 562.0 | nM | 24 | hr | 392.11 | 62.32 | p-S6 | 10.64 | |