Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | AU565 | 3.16 | uM | 24 | hr | 355.81 | 74.70 | p-Akt | 40.56 | |
| Torkinib | AU565 | 2.37 | uM | 6 | hr | 334.47 | 55.96 | p-Akt | 14.59 | |
| Torkinib | AU565 | 2.37 | uM | 24 | hr | 406.69 | 64.21 | p-Akt | 19.47 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 328.03 | 69.27 | p-Akt | 17.72 | |
| GSK1059615 | AU565 | 3.16 | uM | 24 | hr | 365.42 | 74.64 | p-Akt | 20.66 | |
| MK2206 | AU565 | 3.16 | uM | 6 | hr | 321.05 | 67.77 | p-Akt | 15.69 | |
| MK2206 | AU565 | 3.16 | uM | 24 | hr | 339.94 | 67.81 | p-Akt | 19.06 | |
| Triciribine | AU565 | 3.16 | uM | 6 | hr | 214.36 | 53.73 | p-Akt | 14.71 | |
| Triciribine | AU565 | 3.16 | uM | 24 | hr | 450.08 | 73.05 | p-Akt | 34.69 | |
| Dactolisib | AU565 | 3.16 | uM | 6 | hr | 191.19 | 40.59 | p-Akt | 11.70 | |
| Dactolisib | AU565 | 3.16 | uM | 24 | hr | 475.12 | 63.41 | p-Akt | 22.07 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 127.13 | 37.66 | p-Akt | 19.29 | |
| Gefitinib | HCC1954 | 3.16 | uM | 24 | hr | 261.18 | 80.70 | p-Akt | 54.92 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 268.74 | 56.54 | p-Akt | 13.02 | |
| Torkinib | HCC1954 | 2.37 | uM | 24 | hr | 249.07 | 61.10 | p-Akt | 16.22 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 6 | hr | 431.21 | 75.16 | p-Akt | 24.13 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 24 | hr | 314.00 | 58.47 | p-Akt | 19.76 | |
| MK2206 | HCC1954 | 3.16 | uM | 6 | hr | 181.47 | 56.47 | p-Akt | 13.18 | |
| MK2206 | HCC1954 | 3.16 | uM | 24 | hr | 269.15 | 73.62 | p-Akt | 19.68 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 264.60 | 88.34 | p-Akt | 31.68 | |
| Triciribine | HCC1954 | 3.16 | uM | 24 | hr | 232.65 | 92.47 | p-Akt | 28.35 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 195.19 | 57.19 | p-Akt | 14.48 | |
| Dactolisib | HCC1954 | 3.16 | uM | 24 | hr | 266.94 | 62.78 | p-Akt | 17.00 | |
| Gefitinib | MCF 10A | 3.16 | uM | 6 | hr | 189.19 | 137.76 | p-Akt | 27.24 | |
| Gefitinib | MCF 10A | 3.16 | uM | 24 | hr | 206.94 | 27.53 | p-Akt | 24.17 | |