Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | HCC1954 | 10.0 | uM | 24 | hr | 246.75 | 76.42 | p-4EBP1 | 132.19 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 262.84 | 54.87 | p-4EBP1 | 11.12 | |
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 249.22 | 62.64 | p-4EBP1 | 12.82 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 378.26 | 69.22 | p-4EBP1 | 9.39 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 24 | hr | 294.01 | 62.21 | p-4EBP1 | 9.96 | |
| MK2206 | HCC1954 | 10.0 | uM | 6 | hr | 256.91 | 71.73 | p-4EBP1 | 87.38 | |
| MK2206 | HCC1954 | 10.0 | uM | 24 | hr | 259.67 | 64.61 | p-4EBP1 | 65.54 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 241.45 | 75.92 | p-4EBP1 | 117.57 | |
| Triciribine | HCC1954 | 10.0 | uM | 24 | hr | 226.44 | 92.93 | p-4EBP1 | 103.28 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 244.01 | 73.65 | p-4EBP1 | 11.20 | |
| Dactolisib | HCC1954 | 10.0 | uM | 24 | hr | 263.67 | 83.37 | p-4EBP1 | 15.80 | |
| Gefitinib | MCF 10A | 10.0 | uM | 6 | hr | 182.92 | 118.34 | p-4EBP1 | 275.93 | |
| Gefitinib | MCF 10A | 10.0 | uM | 24 | hr | 178.43 | 26.75 | p-4EBP1 | 176.62 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 545.59 | 138.86 | p-4EBP1 | 8.61 | |
| Torkinib | MCF 10A | 10.0 | uM | 24 | hr | 370.27 | 75.35 | p-4EBP1 | 18.52 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 215.54 | 112.60 | p-4EBP1 | 10.21 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 24 | hr | 195.03 | 76.13 | p-4EBP1 | 7.70 | |
| MK2206 | MCF 10A | 10.0 | uM | 6 | hr | 353.40 | 138.38 | p-4EBP1 | 315.42 | |
| MK2206 | MCF 10A | 10.0 | uM | 24 | hr | 309.51 | 88.90 | p-4EBP1 | 144.45 | |
| Triciribine | MCF 10A | 10.0 | uM | 6 | hr | 353.36 | 139.24 | p-4EBP1 | 315.88 | |
| Triciribine | MCF 10A | 10.0 | uM | 24 | hr | 285.94 | 99.29 | p-4EBP1 | 213.75 | |
| Dactolisib | MCF 10A | 10.0 | uM | 6 | hr | 274.72 | 125.82 | p-4EBP1 | 6.11 | |
| Dactolisib | MCF 10A | 10.0 | uM | 24 | hr | 359.33 | 78.50 | p-4EBP1 | 14.74 | |
| Gefitinib | T47D | 10.0 | uM | 6 | hr | 151.92 | 89.36 | p-4EBP1 | 456.82 | |
| Gefitinib | T47D | 10.0 | uM | 24 | hr | 132.66 | 79.82 | p-4EBP1 | 376.65 | |