Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 440.89 | 99.20 | p-4EBP1 | 147.59 | |
| GSK1059615 | AU565 | 31.6 | nM | 6 | hr | 266.90 | 67.18 | p-4EBP1 | 86.16 | |
| GSK1059615 | AU565 | 31.6 | nM | 24 | hr | 464.06 | 126.07 | p-4EBP1 | 178.40 | |
| MK2206 | AU565 | 31.6 | nM | 6 | hr | 255.74 | 64.02 | p-4EBP1 | 86.03 | |
| MK2206 | AU565 | 31.6 | nM | 24 | hr | 367.02 | 117.76 | p-4EBP1 | 165.52 | |
| Triciribine | AU565 | 31.6 | nM | 6 | hr | 349.86 | 83.99 | p-4EBP1 | 125.84 | |
| Triciribine | AU565 | 31.6 | nM | 24 | hr | 499.46 | 124.57 | p-4EBP1 | 196.58 | |
| Dactolisib | AU565 | 31.6 | nM | 6 | hr | 264.17 | 56.83 | p-4EBP1 | 33.37 | |
| Dactolisib | AU565 | 31.6 | nM | 24 | hr | 408.64 | 76.41 | p-4EBP1 | 77.73 | |
| Gefitinib | HCC1954 | 31.6 | nM | 6 | hr | 185.05 | 50.15 | p-4EBP1 | 68.91 | |
| Gefitinib | HCC1954 | 31.6 | nM | 24 | hr | 270.46 | 128.49 | p-4EBP1 | 136.05 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 176.66 | 32.26 | p-4EBP1 | 41.13 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 252.28 | 107.51 | p-4EBP1 | 112.23 | |
| GSK1059615 | HCC1954 | 31.6 | nM | 6 | hr | 274.65 | 82.84 | p-4EBP1 | 93.37 | |
| GSK1059615 | HCC1954 | 31.6 | nM | 24 | hr | 288.77 | 118.12 | p-4EBP1 | 126.97 | |
| MK2206 | HCC1954 | 31.6 | nM | 6 | hr | 242.21 | 77.05 | p-4EBP1 | 103.37 | |
| MK2206 | HCC1954 | 31.6 | nM | 24 | hr | 308.69 | 125.19 | p-4EBP1 | 149.50 | |
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 250.28 | 91.52 | p-4EBP1 | 117.60 | |
| Triciribine | HCC1954 | 31.6 | nM | 24 | hr | 268.23 | 117.03 | p-4EBP1 | 128.35 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 190.11 | 67.14 | p-4EBP1 | 26.14 | |
| Dactolisib | HCC1954 | 31.6 | nM | 24 | hr | 259.09 | 89.65 | p-4EBP1 | 38.06 | |
| Gefitinib | MCF 10A | 31.6 | nM | 6 | hr | 404.00 | 166.61 | p-4EBP1 | 295.81 | |
| Gefitinib | MCF 10A | 31.6 | nM | 24 | hr | 254.64 | 161.24 | p-4EBP1 | 186.14 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 448.64 | 163.43 | p-4EBP1 | 292.01 | |
| Torkinib | MCF 10A | 7.5 | nM | 24 | hr | 362.68 | 177.31 | p-4EBP1 | 160.77 | |