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Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Dactolisib	HCC1954	31.6	nM	24	hr	297.37	88.73	p-S6	20.91
Gefitinib	MCF 10A	31.6	nM	6	hr	393.79	169.73	p-S6	446.82
Gefitinib	MCF 10A	31.6	nM	24	hr	351.27	188.69	p-S6	357.23
Torkinib	MCF 10A	7.5	nM	6	hr	466.14	166.31	p-S6	576.27
Torkinib	MCF 10A	7.5	nM	24	hr	455.61	175.00	p-S6	479.38
GSK1059615	MCF 10A	31.6	nM	6	hr	364.24	165.51	p-S6	487.38
GSK1059615	MCF 10A	31.6	nM	24	hr	310.86	159.77	p-S6	358.78
MK2206	MCF 10A	31.6	nM	6	hr	385.30	156.59	p-S6	445.48
MK2206	MCF 10A	31.6	nM	24	hr	271.77	154.99	p-S6	248.63
Triciribine	MCF 10A	31.6	nM	6	hr	385.84	157.07	p-S6	446.88
Triciribine	MCF 10A	31.6	nM	24	hr	252.91	139.46	p-S6	210.61
Dactolisib	MCF 10A	31.6	nM	6	hr	370.10	148.60	p-S6	439.13
Dactolisib	MCF 10A	31.6	nM	24	hr	270.07	139.60	p-S6	250.53
Gefitinib	T47D	31.6	nM	6	hr	174.35	106.20	p-S6	485.64
Gefitinib	T47D	31.6	nM	24	hr	151.85	119.39	p-S6	339.11
Torkinib	T47D	7.5	nM	6	hr	184.86	113.82	p-S6	367.66
Torkinib	T47D	7.5	nM	24	hr	139.90	103.43	p-S6	294.61
GSK1059615	T47D	31.6	nM	6	hr	190.67	101.75	p-S6	456.84
GSK1059615	T47D	31.6	nM	24	hr	174.61	103.71	p-S6	326.67
MK2206	T47D	31.6	nM	6	hr	105.22	36.75	p-S6	43.27
MK2206	T47D	31.6	nM	24	hr	143.74	105.54	p-S6	421.24
Triciribine	T47D	31.6	nM	6	hr	116.47	75.03	p-S6	164.18
Triciribine	T47D	31.6	nM	24	hr	169.86	105.29	p-S6	392.27
Dactolisib	T47D	31.6	nM	6	hr	90.16	29.57	p-S6	4.68
Dactolisib	T47D	31.6	nM	24	hr	124.69	58.78	p-S6	12.06

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