Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 10.0 | nM | 6 | hr | 105.01 | 63.99 | p-S6 | 46.27 | |
| Dactolisib | T47D | 10.0 | nM | 24 | hr | 134.63 | 107.17 | p-S6 | 225.51 | |
| Gefitinib | AU565 | 31.6 | nM | 6 | hr | 267.09 | 64.29 | p-S6 | 140.82 | |
| Gefitinib | AU565 | 31.6 | nM | 24 | hr | 567.90 | 126.35 | p-S6 | 538.04 | |
| Torkinib | AU565 | 7.5 | nM | 6 | hr | 383.95 | 66.61 | p-S6 | 58.91 | |
| Torkinib | AU565 | 7.5 | nM | 24 | hr | 465.15 | 97.95 | p-S6 | 212.59 | |
| GSK1059615 | AU565 | 31.6 | nM | 6 | hr | 214.88 | 54.28 | p-S6 | 100.03 | |
| GSK1059615 | AU565 | 31.6 | nM | 24 | hr | 474.90 | 120.78 | p-S6 | 524.74 | |
| MK2206 | AU565 | 31.6 | nM | 6 | hr | 316.88 | 74.06 | p-S6 | 151.34 | |
| MK2206 | AU565 | 31.6 | nM | 24 | hr | 405.92 | 121.43 | p-S6 | 442.43 | |
| Triciribine | AU565 | 31.6 | nM | 6 | hr | 344.17 | 86.24 | p-S6 | 215.81 | |
| Triciribine | AU565 | 31.6 | nM | 24 | hr | 558.65 | 122.04 | p-S6 | 463.83 | |
| Dactolisib | AU565 | 31.6 | nM | 6 | hr | 214.57 | 42.34 | p-S6 | 13.61 | |
| Dactolisib | AU565 | 31.6 | nM | 24 | hr | 459.97 | 76.15 | p-S6 | 19.20 | |
| Gefitinib | HCC1954 | 31.6 | nM | 6 | hr | 272.13 | 81.18 | p-S6 | 189.49 | |
| Gefitinib | HCC1954 | 31.6 | nM | 24 | hr | 294.80 | 125.45 | p-S6 | 314.96 | |
| Torkinib | HCC1954 | 7.5 | nM | 6 | hr | 176.81 | 34.82 | p-S6 | 63.14 | |
| Torkinib | HCC1954 | 7.5 | nM | 24 | hr | 296.88 | 108.29 | p-S6 | 416.40 | |
| GSK1059615 | HCC1954 | 31.6 | nM | 6 | hr | 219.87 | 78.30 | p-S6 | 148.50 | |
| GSK1059615 | HCC1954 | 31.6 | nM | 24 | hr | 302.17 | 107.04 | p-S6 | 360.08 | |
| MK2206 | HCC1954 | 31.6 | nM | 6 | hr | 203.08 | 66.19 | p-S6 | 148.30 | |
| MK2206 | HCC1954 | 31.6 | nM | 24 | hr | 277.79 | 115.44 | p-S6 | 293.71 | |
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 251.68 | 83.63 | p-S6 | 314.85 | |
| Triciribine | HCC1954 | 31.6 | nM | 24 | hr | 285.62 | 107.67 | p-S6 | 291.64 | |
| Dactolisib | HCC1954 | 31.6 | nM | 6 | hr | 155.80 | 36.19 | p-S6 | 9.19 | |