Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | T47D | 10.0 | uM | 6 | hr | 166.48 | 70.30 | p-4EBP1 | 22.16 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 123.65 | 43.82 | p-4EBP1 | 9.57 | |
| GSK1059615 | T47D | 10.0 | uM | 6 | hr | 167.66 | 60.97 | p-4EBP1 | 61.20 | |
| GSK1059615 | T47D | 10.0 | uM | 24 | hr | 241.99 | 78.61 | p-4EBP1 | 83.28 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 108.84 | 30.13 | p-4EBP1 | 73.21 | |
| MK2206 | T47D | 10.0 | uM | 24 | hr | 170.32 | 56.12 | p-4EBP1 | 298.67 | |
| Triciribine | T47D | 10.0 | uM | 6 | hr | 123.81 | 62.32 | p-4EBP1 | 229.51 | |
| Triciribine | T47D | 10.0 | uM | 24 | hr | 161.71 | 63.81 | p-4EBP1 | 339.90 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 90.13 | 33.66 | p-4EBP1 | 5.00 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 136.52 | 124.81 | p-4EBP1 | 16.23 | |
| Gefitinib | AU565 | 0 (control) | 6 | hr | 305.86 | 66.00 | p-S6 | 165.72 | | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 612.84 | 138.04 | p-S6 | 527.40 | | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 242.92 | 59.35 | p-S6 | 146.55 | | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 557.64 | 128.55 | p-S6 | 521.30 | | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 265.42 | 70.65 | p-S6 | 168.80 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 451.46 | 118.58 | p-S6 | 522.55 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 277.65 | 78.69 | p-S6 | 159.10 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 458.85 | 128.23 | p-S6 | 525.22 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 344.99 | 87.13 | p-S6 | 242.25 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 513.50 | 123.82 | p-S6 | 483.08 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 246.18 | 58.17 | p-S6 | 130.86 | | |
| Dactolisib | AU565 | 0 (control) | 24 | hr | 529.58 | 125.56 | p-S6 | 517.92 | | |
| Gefitinib | HCC1954 | 0 (control) | 6 | hr | 203.63 | 52.10 | p-S6 | 78.68 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 306.31 | 118.13 | p-S6 | 303.02 | | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 198.88 | 47.14 | p-S6 | 108.01 | |