Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 164.15 | 94.07 | p-4EBP1 | 487.98 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 137.24 | 97.28 | p-4EBP1 | 368.05 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 146.16 | 71.41 | p-4EBP1 | 22.44 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 113.67 | 41.15 | p-4EBP1 | 11.39 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 165.59 | 58.61 | p-4EBP1 | 184.46 | |
| GSK1059615 | T47D | 3.16 | uM | 24 | hr | 183.40 | 74.39 | p-4EBP1 | 200.56 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 97.54 | 39.77 | p-4EBP1 | 105.23 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 150.89 | 47.06 | p-4EBP1 | 268.65 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 111.81 | 55.08 | p-4EBP1 | 181.57 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 158.01 | 75.53 | p-4EBP1 | 342.91 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 84.83 | 32.58 | p-4EBP1 | 4.80 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 117.81 | 50.15 | p-4EBP1 | 8.88 | |
| Gefitinib | AU565 | 10.0 | uM | 6 | hr | 216.77 | 47.93 | p-4EBP1 | 49.07 | |
| Gefitinib | AU565 | 10.0 | uM | 24 | hr | 372.85 | 88.12 | p-4EBP1 | 93.08 | |
| Torkinib | AU565 | 10.0 | uM | 6 | hr | 278.86 | 47.96 | p-4EBP1 | 7.87 | |
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 429.86 | 78.50 | p-4EBP1 | 15.32 | |
| GSK1059615 | AU565 | 10.0 | uM | 6 | hr | 266.02 | 61.23 | p-4EBP1 | 10.38 | |
| GSK1059615 | AU565 | 10.0 | uM | 24 | hr | 316.18 | 83.54 | p-4EBP1 | 15.50 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 311.09 | 61.50 | p-4EBP1 | 70.16 | |
| MK2206 | AU565 | 10.0 | uM | 24 | hr | 328.22 | 69.48 | p-4EBP1 | 83.40 | |
| Triciribine | AU565 | 10.0 | uM | 6 | hr | 274.26 | 62.67 | p-4EBP1 | 52.75 | |
| Triciribine | AU565 | 10.0 | uM | 24 | hr | 387.71 | 67.15 | p-4EBP1 | 78.13 | |
| Dactolisib | AU565 | 10.0 | uM | 6 | hr | 407.30 | 96.21 | p-4EBP1 | 8.68 | |
| Dactolisib | AU565 | 10.0 | uM | 24 | hr | 457.40 | 71.98 | p-4EBP1 | 10.69 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 163.33 | 57.99 | p-4EBP1 | 74.65 | |