Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 1.0 | nM | 24 | hr | 139.38 | 100.34 | p-4EBP1 | 323.20 | |
| Gefitinib | AU565 | 3.16 | nM | 6 | hr | 235.59 | 52.34 | p-4EBP1 | 50.68 | |
| Gefitinib | AU565 | 3.16 | nM | 24 | hr | 567.47 | 140.54 | p-4EBP1 | 166.16 | |
| Torkinib | AU565 | 0.422 | nM | 6 | hr | 325.27 | 66.60 | p-4EBP1 | 88.50 | |
| Torkinib | AU565 | 0.422 | nM | 24 | hr | 462.08 | 119.67 | p-4EBP1 | 200.90 | |
| GSK1059615 | AU565 | 3.16 | nM | 6 | hr | 279.66 | 70.10 | p-4EBP1 | 86.62 | |
| GSK1059615 | AU565 | 3.16 | nM | 24 | hr | 461.44 | 121.03 | p-4EBP1 | 176.71 | |
| MK2206 | AU565 | 3.16 | nM | 6 | hr | 207.40 | 54.85 | p-4EBP1 | 68.29 | |
| MK2206 | AU565 | 3.16 | nM | 24 | hr | 384.49 | 131.77 | p-4EBP1 | 191.65 | |
| Triciribine | AU565 | 3.16 | nM | 6 | hr | 336.77 | 87.01 | p-4EBP1 | 121.09 | |
| Triciribine | AU565 | 3.16 | nM | 24 | hr | 480.11 | 134.11 | p-4EBP1 | 213.24 | |
| Dactolisib | AU565 | 3.16 | nM | 6 | hr | 213.94 | 51.94 | p-4EBP1 | 62.87 | |
| Dactolisib | AU565 | 3.16 | nM | 24 | hr | 505.04 | 119.83 | p-4EBP1 | 175.81 | |
| Gefitinib | HCC1954 | 3.16 | nM | 6 | hr | 131.67 | 28.62 | p-4EBP1 | 36.83 | |
| Gefitinib | HCC1954 | 3.16 | nM | 24 | hr | 247.32 | 124.64 | p-4EBP1 | 127.73 | |
| Torkinib | HCC1954 | 0.422 | nM | 6 | hr | 168.42 | 32.42 | p-4EBP1 | 42.36 | |
| Torkinib | HCC1954 | 0.422 | nM | 24 | hr | 272.73 | 120.17 | p-4EBP1 | 122.70 | |
| GSK1059615 | HCC1954 | 3.16 | nM | 6 | hr | 296.05 | 77.18 | p-4EBP1 | 87.72 | |
| GSK1059615 | HCC1954 | 3.16 | nM | 24 | hr | 259.39 | 116.67 | p-4EBP1 | 122.67 | |
| MK2206 | HCC1954 | 3.16 | nM | 6 | hr | 231.66 | 69.95 | p-4EBP1 | 91.88 | |
| MK2206 | HCC1954 | 3.16 | nM | 24 | hr | 270.27 | 124.39 | p-4EBP1 | 138.37 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 289.18 | 96.47 | p-4EBP1 | 120.20 | |
| Triciribine | HCC1954 | 3.16 | nM | 24 | hr | 321.97 | 119.92 | p-4EBP1 | 138.73 | |
| Dactolisib | HCC1954 | 3.16 | nM | 6 | hr | 156.03 | 43.22 | p-4EBP1 | 57.72 | |
| Dactolisib | HCC1954 | 3.16 | nM | 24 | hr | 287.27 | 107.15 | p-4EBP1 | 136.44 | |