Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 159.76 | 114.64 | p-Akt | 81.98 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 153.21 | 83.29 | p-Akt | 22.78 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 115.96 | 35.31 | p-Akt | 16.90 | |
| GSK1059615 | T47D | 316.0 | nM | 6 | hr | 155.22 | 70.63 | p-Akt | 39.74 | |
| GSK1059615 | T47D | 316.0 | nM | 24 | hr | 145.35 | 43.87 | p-Akt | 26.14 | |
| MK2206 | T47D | 316.0 | nM | 6 | hr | 106.17 | 51.36 | p-Akt | 7.32 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 133.77 | 58.56 | p-Akt | 14.98 | |
| Triciribine | T47D | 316.0 | nM | 6 | hr | 114.81 | 51.70 | p-Akt | 11.93 | |
| Triciribine | T47D | 316.0 | nM | 24 | hr | 167.32 | 71.34 | p-Akt | 37.26 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 92.43 | 45.00 | p-Akt | 6.96 | |
| Dactolisib | T47D | 316.0 | nM | 24 | hr | 116.03 | 41.14 | p-Akt | 14.73 | |
| Gefitinib | AU565 | 1.0 | uM | 6 | hr | 234.22 | 57.81 | p-Akt | 20.79 | |
| Gefitinib | AU565 | 1.0 | uM | 24 | hr | 360.24 | 81.24 | p-Akt | 78.24 | |
| Torkinib | AU565 | 562.0 | nM | 6 | hr | 301.77 | 52.75 | p-Akt | 13.61 | |
| Torkinib | AU565 | 562.0 | nM | 24 | hr | 401.07 | 58.87 | p-Akt | 18.56 | |
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 216.34 | 42.62 | p-Akt | 17.65 | |
| GSK1059615 | AU565 | 1.0 | uM | 24 | hr | 419.10 | 71.76 | p-Akt | 30.83 | |
| MK2206 | AU565 | 1.0 | uM | 6 | hr | 260.81 | 58.97 | p-Akt | 13.43 | |
| MK2206 | AU565 | 1.0 | uM | 24 | hr | 360.93 | 75.24 | p-Akt | 21.10 | |
| Triciribine | AU565 | 1.0 | uM | 6 | hr | 295.69 | 71.82 | p-Akt | 19.96 | |
| Triciribine | AU565 | 1.0 | uM | 24 | hr | 442.50 | 77.06 | p-Akt | 37.03 | |
| Dactolisib | AU565 | 1.0 | uM | 6 | hr | 327.69 | 72.03 | p-Akt | 17.75 | |
| Dactolisib | AU565 | 1.0 | uM | 24 | hr | 409.59 | 57.48 | p-Akt | 21.16 | |
| Gefitinib | HCC1954 | 1.0 | uM | 6 | hr | 135.01 | 33.51 | p-Akt | 20.62 | |
| Gefitinib | HCC1954 | 1.0 | uM | 24 | hr | 240.65 | 87.74 | p-Akt | 64.52 | |