Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 167.72 | 46.85 | p-4EBP1 | 64.61 | |
| Dactolisib | HCC1954 | 1.0 | nM | 24 | hr | 301.34 | 115.11 | p-4EBP1 | 140.89 | |
| Gefitinib | MCF 10A | 1.0 | nM | 6 | hr | 422.92 | 158.40 | p-4EBP1 | 303.02 | |
| Gefitinib | MCF 10A | 1.0 | nM | 24 | hr | 300.92 | 152.97 | p-4EBP1 | 337.34 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 452.64 | 159.11 | p-4EBP1 | 351.84 | |
| Torkinib | MCF 10A | 0.1 | nM | 24 | hr | 314.74 | 144.81 | p-4EBP1 | 313.68 | |
| GSK1059615 | MCF 10A | 1.0 | nM | 6 | hr | 411.52 | 169.82 | p-4EBP1 | 367.85 | |
| GSK1059615 | MCF 10A | 1.0 | nM | 24 | hr | 298.52 | 143.98 | p-4EBP1 | 335.89 | |
| MK2206 | MCF 10A | 1.0 | nM | 6 | hr | 424.87 | 161.04 | p-4EBP1 | 383.69 | |
| MK2206 | MCF 10A | 1.0 | nM | 24 | hr | 277.61 | 143.74 | p-4EBP1 | 324.15 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 427.06 | 161.76 | p-4EBP1 | 385.00 | |
| Triciribine | MCF 10A | 1.0 | nM | 24 | hr | 266.33 | 138.95 | p-4EBP1 | 314.28 | |
| Dactolisib | MCF 10A | 1.0 | nM | 6 | hr | 412.87 | 154.76 | p-4EBP1 | 376.60 | |
| Dactolisib | MCF 10A | 1.0 | nM | 24 | hr | 272.56 | 144.30 | p-4EBP1 | 309.29 | |
| Gefitinib | T47D | 1.0 | nM | 6 | hr | 183.90 | 97.22 | p-4EBP1 | 480.82 | |
| Gefitinib | T47D | 1.0 | nM | 24 | hr | 162.03 | 128.99 | p-4EBP1 | 428.64 | |
| Torkinib | T47D | 0.1 | nM | 6 | hr | 176.85 | 88.19 | p-4EBP1 | 516.23 | |
| Torkinib | T47D | 0.1 | nM | 24 | hr | 157.07 | 112.77 | p-4EBP1 | 421.70 | |
| GSK1059615 | T47D | 1.0 | nM | 6 | hr | 165.02 | 87.79 | p-4EBP1 | 472.54 | |
| GSK1059615 | T47D | 1.0 | nM | 24 | hr | 166.74 | 106.91 | p-4EBP1 | 414.51 | |
| MK2206 | T47D | 1.0 | nM | 6 | hr | 99.92 | 49.23 | p-4EBP1 | 113.45 | |
| MK2206 | T47D | 1.0 | nM | 24 | hr | 157.01 | 111.64 | p-4EBP1 | 403.64 | |
| Triciribine | T47D | 1.0 | nM | 6 | hr | 110.91 | 60.35 | p-4EBP1 | 189.17 | |
| Triciribine | T47D | 1.0 | nM | 24 | hr | 147.16 | 105.16 | p-4EBP1 | 366.06 | |
| Dactolisib | T47D | 1.0 | nM | 6 | hr | 95.66 | 52.97 | p-4EBP1 | 132.08 | |