Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | MCF 10A | 316.0 | nM | 6 | hr | 375.95 | 152.24 | p-4EBP1 | 348.65 | |
| Triciribine | MCF 10A | 316.0 | nM | 24 | hr | 246.69 | 149.87 | p-4EBP1 | 169.66 | |
| Dactolisib | MCF 10A | 316.0 | nM | 6 | hr | 337.51 | 115.36 | p-4EBP1 | 15.42 | |
| Dactolisib | MCF 10A | 316.0 | nM | 24 | hr | 319.08 | 53.99 | p-4EBP1 | 8.38 | |
| Gefitinib | T47D | 316.0 | nM | 6 | hr | 168.46 | 99.26 | p-4EBP1 | 489.94 | |
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 135.34 | 103.12 | p-4EBP1 | 378.08 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 150.81 | 73.17 | p-4EBP1 | 136.18 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 115.14 | 43.04 | p-4EBP1 | 81.95 | |
| GSK1059615 | T47D | 316.0 | nM | 6 | hr | 161.83 | 71.64 | p-4EBP1 | 484.10 | |
| GSK1059615 | T47D | 316.0 | nM | 24 | hr | 141.09 | 48.36 | p-4EBP1 | 354.98 | |
| MK2206 | T47D | 316.0 | nM | 6 | hr | 97.21 | 44.14 | p-4EBP1 | 106.54 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 131.03 | 70.58 | p-4EBP1 | 321.88 | |
| Triciribine | T47D | 316.0 | nM | 6 | hr | 108.37 | 50.60 | p-4EBP1 | 160.52 | |
| Triciribine | T47D | 316.0 | nM | 24 | hr | 165.28 | 84.19 | p-4EBP1 | 347.08 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 86.15 | 33.76 | p-4EBP1 | 14.31 | |
| Dactolisib | T47D | 316.0 | nM | 24 | hr | 101.46 | 37.88 | p-4EBP1 | 24.34 | |
| Gefitinib | AU565 | 1.0 | uM | 6 | hr | 236.79 | 58.62 | p-4EBP1 | 75.30 | |
| Gefitinib | AU565 | 1.0 | uM | 24 | hr | 366.24 | 89.40 | p-4EBP1 | 127.46 | |
| Torkinib | AU565 | 562.0 | nM | 6 | hr | 250.73 | 44.18 | p-4EBP1 | 7.70 | |
| Torkinib | AU565 | 562.0 | nM | 24 | hr | 391.61 | 66.24 | p-4EBP1 | 12.45 | |
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 323.04 | 68.35 | p-4EBP1 | 78.89 | |
| GSK1059615 | AU565 | 1.0 | uM | 24 | hr | 436.35 | 80.55 | p-4EBP1 | 88.08 | |
| MK2206 | AU565 | 1.0 | uM | 6 | hr | 316.22 | 67.25 | p-4EBP1 | 94.25 | |
| MK2206 | AU565 | 1.0 | uM | 24 | hr | 341.24 | 76.08 | p-4EBP1 | 106.62 | |
| Triciribine | AU565 | 1.0 | uM | 6 | hr | 319.34 | 76.84 | p-4EBP1 | 95.24 | |