Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AU565 | 1.0 | uM | 24 | hr | 456.10 | 90.01 | p-4EBP1 | 126.32 | |
| Dactolisib | AU565 | 1.0 | uM | 6 | hr | 229.24 | 51.96 | p-4EBP1 | 8.38 | |
| Dactolisib | AU565 | 1.0 | uM | 24 | hr | 447.91 | 63.52 | p-4EBP1 | 10.50 | |
| Gefitinib | HCC1954 | 1.0 | uM | 6 | hr | 128.30 | 38.07 | p-4EBP1 | 57.69 | |
| Gefitinib | HCC1954 | 1.0 | uM | 24 | hr | 260.61 | 103.02 | p-4EBP1 | 127.87 | |
| Torkinib | HCC1954 | 562.0 | nM | 6 | hr | 183.48 | 36.52 | p-4EBP1 | 10.85 | |
| Torkinib | HCC1954 | 562.0 | nM | 24 | hr | 232.92 | 77.12 | p-4EBP1 | 22.91 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 6 | hr | 421.88 | 76.75 | p-4EBP1 | 47.94 | |
| GSK1059615 | HCC1954 | 1.0 | uM | 24 | hr | 264.29 | 66.78 | p-4EBP1 | 30.96 | |
| MK2206 | HCC1954 | 1.0 | uM | 6 | hr | 239.11 | 68.86 | p-4EBP1 | 90.25 | |
| MK2206 | HCC1954 | 1.0 | uM | 24 | hr | 248.06 | 98.57 | p-4EBP1 | 126.15 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 262.74 | 87.39 | p-4EBP1 | 128.31 | |
| Triciribine | HCC1954 | 1.0 | uM | 24 | hr | 216.58 | 102.83 | p-4EBP1 | 109.56 | |
| Dactolisib | HCC1954 | 1.0 | uM | 6 | hr | 254.85 | 75.26 | p-4EBP1 | 10.90 | |
| Dactolisib | HCC1954 | 1.0 | uM | 24 | hr | 266.62 | 68.42 | p-4EBP1 | 14.69 | |
| Gefitinib | MCF 10A | 1.0 | uM | 6 | hr | 174.20 | 136.88 | p-4EBP1 | 290.22 | |
| Gefitinib | MCF 10A | 1.0 | uM | 24 | hr | 170.09 | 36.89 | p-4EBP1 | 134.39 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 553.63 | 148.24 | p-4EBP1 | 36.47 | |
| Torkinib | MCF 10A | 562.0 | nM | 24 | hr | 415.77 | 104.89 | p-4EBP1 | 37.62 | |
| GSK1059615 | MCF 10A | 1.0 | uM | 6 | hr | 241.39 | 127.81 | p-4EBP1 | 86.97 | |
| GSK1059615 | MCF 10A | 1.0 | uM | 24 | hr | 244.26 | 89.76 | p-4EBP1 | 54.72 | |
| MK2206 | MCF 10A | 1.0 | uM | 6 | hr | 361.83 | 145.33 | p-4EBP1 | 338.66 | |
| MK2206 | MCF 10A | 1.0 | uM | 24 | hr | 344.63 | 180.54 | p-4EBP1 | 202.39 | |
| Triciribine | MCF 10A | 1.0 | uM | 6 | hr | 362.80 | 146.62 | p-4EBP1 | 339.35 | |
| Triciribine | MCF 10A | 1.0 | uM | 24 | hr | 259.30 | 148.61 | p-4EBP1 | 183.14 | |