Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | MCF 10A | 0.1 | nM | 24 | hr | 440.38 | 152.72 | p-S6 | 429.06 | |
| GSK1059615 | MCF 10A | 1.0 | nM | 6 | hr | 449.62 | 182.84 | p-S6 | 658.02 | |
| GSK1059615 | MCF 10A | 1.0 | nM | 24 | hr | 485.63 | 165.59 | p-S6 | 430.02 | |
| MK2206 | MCF 10A | 1.0 | nM | 6 | hr | 426.62 | 156.09 | p-S6 | 543.93 | |
| MK2206 | MCF 10A | 1.0 | nM | 24 | hr | 345.33 | 143.16 | p-S6 | 297.97 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 427.45 | 156.76 | p-S6 | 544.61 | |
| Triciribine | MCF 10A | 1.0 | nM | 24 | hr | 347.89 | 124.44 | p-S6 | 314.69 | |
| Dactolisib | MCF 10A | 1.0 | nM | 6 | hr | 451.01 | 161.00 | p-S6 | 615.55 | |
| Dactolisib | MCF 10A | 1.0 | nM | 24 | hr | 363.43 | 135.18 | p-S6 | 346.57 | |
| Gefitinib | T47D | 1.0 | nM | 6 | hr | 186.22 | 98.66 | p-S6 | 445.75 | |
| Gefitinib | T47D | 1.0 | nM | 24 | hr | 154.56 | 110.22 | p-S6 | 330.95 | |
| Torkinib | T47D | 0.1 | nM | 6 | hr | 176.07 | 94.03 | p-S6 | 481.17 | |
| Torkinib | T47D | 0.1 | nM | 24 | hr | 155.25 | 96.73 | p-S6 | 326.61 | |
| GSK1059615 | T47D | 1.0 | nM | 6 | hr | 146.89 | 92.17 | p-S6 | 492.65 | |
| GSK1059615 | T47D | 1.0 | nM | 24 | hr | 155.64 | 93.45 | p-S6 | 329.12 | |
| MK2206 | T47D | 1.0 | nM | 6 | hr | 95.53 | 34.98 | p-S6 | 40.11 | |
| MK2206 | T47D | 1.0 | nM | 24 | hr | 145.38 | 93.63 | p-S6 | 345.92 | |
| Triciribine | T47D | 1.0 | nM | 6 | hr | 98.69 | 46.05 | p-S6 | 45.90 | |
| Triciribine | T47D | 1.0 | nM | 24 | hr | 157.81 | 96.22 | p-S6 | 353.49 | |
| Dactolisib | T47D | 1.0 | nM | 6 | hr | 92.87 | 40.61 | p-S6 | 46.08 | |
| Dactolisib | T47D | 1.0 | nM | 24 | hr | 152.56 | 96.95 | p-S6 | 291.67 | |
| Gefitinib | AU565 | 3.16 | nM | 6 | hr | 250.47 | 55.69 | p-S6 | 122.30 | |
| Gefitinib | AU565 | 3.16 | nM | 24 | hr | 560.89 | 123.46 | p-S6 | 526.76 | |
| Torkinib | AU565 | 0.422 | nM | 6 | hr | 322.35 | 65.11 | p-S6 | 163.11 | |
| Torkinib | AU565 | 0.422 | nM | 24 | hr | 426.83 | 112.18 | p-S6 | 458.36 | |