Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | HCC1954 | 316.0 | nM | 24 | hr | 294.49 | 71.37 | p-4EBP1 | 79.58 | |
| MK2206 | HCC1954 | 316.0 | nM | 6 | hr | 302.23 | 76.14 | p-4EBP1 | 118.15 | |
| MK2206 | HCC1954 | 316.0 | nM | 24 | hr | 257.96 | 111.39 | p-4EBP1 | 136.89 | |
| Triciribine | HCC1954 | 316.0 | nM | 6 | hr | 308.37 | 90.07 | p-4EBP1 | 137.46 | |
| Triciribine | HCC1954 | 316.0 | nM | 24 | hr | 239.36 | 110.40 | p-4EBP1 | 117.63 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 242.45 | 72.32 | p-4EBP1 | 10.51 | |
| Dactolisib | HCC1954 | 316.0 | nM | 24 | hr | 264.80 | 72.43 | p-4EBP1 | 15.57 | |
| Gefitinib | MCF 10A | 316.0 | nM | 6 | hr | 239.67 | 157.19 | p-4EBP1 | 276.80 | |
| Gefitinib | MCF 10A | 316.0 | nM | 24 | hr | 254.25 | 163.29 | p-4EBP1 | 161.19 | |
| Torkinib | MCF 10A | 133.0 | nM | 6 | hr | 501.30 | 154.60 | p-4EBP1 | 88.60 | |
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 438.54 | 156.39 | p-4EBP1 | 79.88 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 6 | hr | 295.71 | 160.20 | p-4EBP1 | 258.30 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 24 | hr | 273.56 | 158.12 | p-4EBP1 | 126.16 | |
| MK2206 | MCF 10A | 316.0 | nM | 6 | hr | 388.13 | 149.70 | p-4EBP1 | 361.95 | |
| MK2206 | MCF 10A | 316.0 | nM | 24 | hr | 286.48 | 176.36 | p-4EBP1 | 204.68 | |
| Triciribine | MCF 10A | 316.0 | nM | 6 | hr | 391.93 | 150.78 | p-4EBP1 | 363.54 | |
| Triciribine | MCF 10A | 316.0 | nM | 24 | hr | 241.16 | 154.04 | p-4EBP1 | 169.17 | |
| Dactolisib | MCF 10A | 316.0 | nM | 6 | hr | 320.35 | 114.77 | p-4EBP1 | 15.78 | |
| Dactolisib | MCF 10A | 316.0 | nM | 24 | hr | 364.25 | 56.36 | p-4EBP1 | 9.92 | |
| Gefitinib | T47D | 316.0 | nM | 6 | hr | 165.96 | 92.35 | p-4EBP1 | 469.89 | |
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 139.46 | 104.96 | p-4EBP1 | 390.50 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 155.10 | 75.38 | p-4EBP1 | 133.39 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 117.10 | 42.82 | p-4EBP1 | 81.20 | |
| GSK1059615 | T47D | 316.0 | nM | 6 | hr | 150.58 | 73.05 | p-4EBP1 | 497.11 | |
| GSK1059615 | T47D | 316.0 | nM | 24 | hr | 133.80 | 47.01 | p-4EBP1 | 338.84 | |