Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | AU565 | 0.1 | nM | 6 | hr | 305.74 | 64.80 | p-S6 | 181.17 | |
| Torkinib | AU565 | 0.1 | nM | 24 | hr | 441.31 | 116.55 | p-S6 | 470.12 | |
| GSK1059615 | AU565 | 1.0 | nM | 6 | hr | 232.38 | 68.41 | p-S6 | 157.56 | |
| GSK1059615 | AU565 | 1.0 | nM | 24 | hr | 407.13 | 109.74 | p-S6 | 496.30 | |
| MK2206 | AU565 | 1.0 | nM | 6 | hr | 380.99 | 91.20 | p-S6 | 338.00 | |
| MK2206 | AU565 | 1.0 | nM | 24 | hr | 402.04 | 124.44 | p-S6 | 527.70 | |
| Triciribine | AU565 | 1.0 | nM | 6 | hr | 342.40 | 88.29 | p-S6 | 283.87 | |
| Triciribine | AU565 | 1.0 | nM | 24 | hr | 492.44 | 120.88 | p-S6 | 499.19 | |
| Dactolisib | AU565 | 1.0 | nM | 6 | hr | 241.54 | 58.04 | p-S6 | 126.41 | |
| Dactolisib | AU565 | 1.0 | nM | 24 | hr | 488.73 | 114.80 | p-S6 | 399.68 | |
| Gefitinib | HCC1954 | 1.0 | nM | 6 | hr | 203.78 | 48.99 | p-S6 | 70.52 | |
| Gefitinib | HCC1954 | 1.0 | nM | 24 | hr | 307.64 | 120.90 | p-S6 | 348.20 | |
| Torkinib | HCC1954 | 0.1 | nM | 6 | hr | 230.43 | 52.31 | p-S6 | 123.13 | |
| Torkinib | HCC1954 | 0.1 | nM | 24 | hr | 291.18 | 108.05 | p-S6 | 406.86 | |
| GSK1059615 | HCC1954 | 1.0 | nM | 6 | hr | 429.19 | 97.66 | p-S6 | 401.57 | |
| GSK1059615 | HCC1954 | 1.0 | nM | 24 | hr | 294.85 | 108.79 | p-S6 | 317.58 | |
| MK2206 | HCC1954 | 1.0 | nM | 6 | hr | 324.58 | 90.78 | p-S6 | 432.26 | |
| MK2206 | HCC1954 | 1.0 | nM | 24 | hr | 308.86 | 120.34 | p-S6 | 312.29 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 228.04 | 80.31 | p-S6 | 267.13 | |
| Triciribine | HCC1954 | 1.0 | nM | 24 | hr | 314.29 | 109.50 | p-S6 | 336.44 | |
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 240.12 | 95.42 | p-S6 | 317.18 | |
| Dactolisib | HCC1954 | 1.0 | nM | 24 | hr | 317.79 | 117.21 | p-S6 | 385.45 | |
| Gefitinib | MCF 10A | 1.0 | nM | 6 | hr | 432.36 | 173.24 | p-S6 | 512.86 | |
| Gefitinib | MCF 10A | 1.0 | nM | 24 | hr | 408.31 | 163.93 | p-S6 | 489.36 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 500.23 | 174.95 | p-S6 | 699.38 | |