Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | T47D | 316.0 | nM | 24 | hr | 146.62 | 102.13 | p-S6 | 354.61 | |
| Torkinib | T47D | 133.0 | nM | 6 | hr | 150.60 | 73.38 | p-S6 | 6.52 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 115.90 | 38.54 | p-S6 | 4.85 | |
| GSK1059615 | T47D | 316.0 | nM | 6 | hr | 158.52 | 78.20 | p-S6 | 45.46 | |
| GSK1059615 | T47D | 316.0 | nM | 24 | hr | 143.95 | 41.36 | p-S6 | 9.52 | |
| MK2206 | T47D | 316.0 | nM | 6 | hr | 96.10 | 37.25 | p-S6 | 27.89 | |
| MK2206 | T47D | 316.0 | nM | 24 | hr | 136.56 | 81.32 | p-S6 | 300.66 | |
| Triciribine | T47D | 316.0 | nM | 6 | hr | 109.57 | 46.13 | p-S6 | 50.30 | |
| Triciribine | T47D | 316.0 | nM | 24 | hr | 161.05 | 81.18 | p-S6 | 431.20 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 91.80 | 41.44 | p-S6 | 3.90 | |
| Dactolisib | T47D | 316.0 | nM | 24 | hr | 110.55 | 38.49 | p-S6 | 5.52 | |
| Gefitinib | AU565 | 1.0 | uM | 6 | hr | 218.20 | 49.17 | p-S6 | 35.46 | |
| Gefitinib | AU565 | 1.0 | uM | 24 | hr | 381.91 | 82.09 | p-S6 | 264.60 | |
| Torkinib | AU565 | 562.0 | nM | 6 | hr | 383.91 | 62.98 | p-S6 | 18.32 | |
| Torkinib | AU565 | 562.0 | nM | 24 | hr | 376.72 | 59.48 | p-S6 | 9.74 | |
| GSK1059615 | AU565 | 1.0 | uM | 6 | hr | 223.90 | 46.95 | p-S6 | 8.84 | |
| GSK1059615 | AU565 | 1.0 | uM | 24 | hr | 410.06 | 64.87 | p-S6 | 21.54 | |
| MK2206 | AU565 | 1.0 | uM | 6 | hr | 311.60 | 70.51 | p-S6 | 88.93 | |
| MK2206 | AU565 | 1.0 | uM | 24 | hr | 362.06 | 77.84 | p-S6 | 133.01 | |
| Triciribine | AU565 | 1.0 | uM | 6 | hr | 356.95 | 84.72 | p-S6 | 194.30 | |
| Triciribine | AU565 | 1.0 | uM | 24 | hr | 523.13 | 92.57 | p-S6 | 246.86 | |
| Dactolisib | AU565 | 1.0 | uM | 6 | hr | 244.28 | 53.82 | p-S6 | 11.73 | |
| Dactolisib | AU565 | 1.0 | uM | 24 | hr | 451.73 | 61.37 | p-S6 | 10.95 | |
| Gefitinib | HCC1954 | 1.0 | uM | 6 | hr | 179.78 | 75.29 | p-S6 | 149.42 | |
| Gefitinib | HCC1954 | 1.0 | uM | 24 | hr | 246.11 | 93.69 | p-S6 | 331.73 | |