Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Gemcitabine | SUM229PE | -3.8416 | 0.8470 | -7.1186 | -6.2995 | -7.0037 | 1.7650 | 0.4821 | 0.4821 | 6.8269 |
| Gemcitabine | SUM52PE | -3.8416 | 0.9073 | -8.0736 | -7.7371 | -8.1643 | 1.2920 | 0.3163 | 0.3163 | 4.6098 |
| Gemcitabine | 184A1 | -3.8416 | 0.8958 | -4.9646 | -4.8599 | -6.3316 | 0.4675 | 0.0532 | 0.2709 | 6.6571 |
| Gemcitabine | MCF12A | -3.8416 | 0.9832 | -7.5536 | -7.4446 | -7.6193 | 1.3900 | 0.1477 | 0.1477 | 4.0962 |
| Gemcitabine | MX1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Gemcitabine | T47DKBLUC | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Gemcitabine | 600MPE | -3.8416 | 0.9498 | -7.8236 | -3.8416 | -7.6369 | 1.2640 | 0.5904 | 0.5904 | 6.5250 |
| Gemcitabine | HCC2185 | -3.8416 | 0.8499 | -7.5826 | -3.8416 | -7.5856 | 2.1275 | 0.7278 | 0.7278 | 7.3709 |
| Gemcitabine | HCC3153 | -3.8416 | 0.8777 | -7.7166 | -3.8416 | -7.0757 | 3.3230 | 0.6587 | 0.6587 | 7.0092 |
| Gemcitabine | LY2 | -3.8416 | 0.9104 | -7.8891 | -3.8416 | -7.6572 | 3.6505 | 0.6534 | 0.6534 | 6.8318 |
| Gemcitabine | ZR75B | -3.8416 | 0.7019 | -7.6686 | -3.8416 | -7.4014 | 3.9460 | 0.7177 | 0.7177 | 7.4982 |
| GSK1838705A | MCF7 | -4.1759 | 0.8977 | -5.8759 | -5.5369 | -6.0785 | 1.3176 | 0.2332 | 0.2512 | 6.7024 |
| GSK1838705A | SK-BR-3 | -4.1759 | 0.9780 | -5.3439 | -5.3351 | -5.4308 | 2.6200 | 0.0259 | 0.0268 | 6.8881 |
| GSK1838705A | MDA-MB-231 | -4.1759 | 0.8626 | -5.3939 | -5.3805 | -5.4071 | 3.9890 | 0.0575 | 0.0575 | 7.2303 |
| GSK1838705A | AU565 | -4.1759 | 0.9774 | -5.5579 | -5.4900 | -5.6148 | 2.4490 | 0.0039 | 0.0045 | 6.5579 |
| GSK1838705A | BT-20 | -4.1759 | 0.7254 | -5.3809 | -5.2943 | -5.4635 | 3.9970 | 0.2736 | 0.2736 | 7.8780 |
| GSK1838705A | BT-474 | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.3415 |
| GSK1838705A | BT-483 | -4.1759 | 0.7767 | -5.4409 | -5.3967 | -5.5872 | 4.0000 | 0.1687 | 0.1687 | 6.7544 |
| GSK1838705A | BT-549 | -4.1759 | 0.9516 | -5.2199 | -5.2198 | -5.2460 | 3.2270 | 0.0000 | 0.0004 | 7.3305 |
| GSK1838705A | CAMA-1 | -4.1759 | 0.9785 | -5.2734 | -5.2637 | -5.3798 | 3.9990 | 0.0436 | 0.0436 | 6.9684 |
| GSK1838705A | HCC1143 | -4.1759 | 0.7093 | -5.5659 | -5.3897 | -5.5152 | 3.9450 | 0.3992 | 0.3992 | 7.5083 |
| GSK1838705A | HCC1395 | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.2454 |
| GSK1838705A | HCC1419 | -4.1759 | 0.9770 | -4.5964 | -4.5964 | -4.8530 | 3.3950 | 0.0000 | 0.0360 | 8.2052 |
| GSK1838705A | HCC1428 | -4.1759 | 0.9400 | -5.4499 | -5.4502 | -5.7088 | 1.8830 | 0.0882 | 0.0882 | 6.4858 |
| GSK1838705A | HCC1569 | -4.1759 | 0.7123 | -5.5339 | -4.1759 | -4.1759 | 3.9930 | 0.7054 | 0.7054 | 8.0994 |