Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Topotecan | 184A1 | -3.9626 | 0.8916 | -6.6386 | -6.1231 | -7.0810 | 0.8042 | 0.3075 | 0.3124 | 5.8239 |
| Topotecan | MCF12A | -3.9626 | 0.9716 | -6.8631 | -6.8630 | -7.6411 | 0.5807 | 0.0000 | 0.0208 | 4.2451 |
| Topotecan | MX1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Topotecan | T47DKBLUC | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Topotecan | 600MPE | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Topotecan | HCC2185 | -3.9626 | 0.8939 | -6.3376 | -3.9626 | -7.3028 | 0.7330 | 0.5374 | 0.5407 | 6.9119 |
| Topotecan | HCC3153 | -3.9626 | 0.9854 | -6.2436 | -6.2064 | -6.6946 | 0.7628 | 0.0315 | 0.0488 | 5.3948 |
| Topotecan | LY2 | -3.9626 | 0.9546 | -6.1176 | -5.9119 | -6.6278 | 0.5455 | 0.1140 | 0.1694 | 5.8004 |
| Topotecan | ZR75B | -3.9626 | 0.9273 | -6.1276 | -6.1279 | -7.2077 | 0.3952 | 0.0000 | 0.1239 | 5.3567 |
| Trichostatin A | MCF7 | -2.3010 | 0.9767 | -5.0140 | -4.9761 | -5.1867 | 1.7175 | 0.0697 | 0.0697 | 4.8153 |
| Trichostatin A | SK-BR-3 | -2.3010 | 0.9858 | -5.1370 | -5.1345 | -5.2881 | 1.6250 | 0.0051 | 0.0052 | 4.2956 |
| Trichostatin A | MDA-MB-231 | -2.3010 | 0.9344 | -4.7750 | -4.7729 | -4.8425 | 3.0270 | 0.0270 | 0.0270 | 5.4185 |
| Trichostatin A | AU565 | -2.3010 | 0.9924 | -5.4325 | -5.4300 | -5.5016 | 2.8975 | 0.0083 | 0.0083 | 4.0767 |
| Trichostatin A | BT-20 | -2.3010 | 0.9801 | -4.6990 | -4.6769 | -4.8947 | 1.9240 | 0.0450 | 0.0451 | 5.0531 |
| Trichostatin A | BT-474 | -2.3010 | 0.9917 | -4.8530 | -4.8448 | -5.0323 | 3.2330 | 0.0300 | 0.0300 | 4.9791 |
| Trichostatin A | BT-483 | -2.3010 | 0.9631 | -4.4250 | -4.3457 | -4.9536 | 1.3160 | 0.1063 | 0.1077 | 5.6402 |
| Trichostatin A | BT-549 | -2.3010 | 0.9764 | -5.0950 | -5.0880 | -5.1310 | 3.0420 | 0.0236 | 0.0236 | 4.8410 |
| Trichostatin A | CAMA-1 | -2.3010 | 0.9721 | -5.0370 | -5.0141 | -5.1708 | 4.0000 | 0.0963 | 0.0963 | 4.8347 |
| Trichostatin A | HCC1143 | -2.3010 | 0.9873 | -4.7580 | -4.7216 | -4.8250 | 2.4610 | 0.0941 | 0.0941 | 5.3980 |
| Trichostatin A | HCC1395 | -2.3010 | 0.9213 | -4.4110 | -4.3755 | -4.6377 | 1.9505 | 0.0727 | 0.0736 | 5.5670 |
| Trichostatin A | HCC1419 | -2.3010 | 0.9849 | -4.3440 | -4.3344 | -4.7769 | 2.2975 | 0.0220 | 0.0221 | 5.4964 |
| Trichostatin A | HCC1428 | -2.3010 | 0.9787 | -5.4660 | -5.4557 | -5.7568 | 2.2110 | 0.0193 | 0.0193 | 4.1335 |
| Trichostatin A | HCC1569 | -2.3010 | 0.8717 | -4.9980 | -4.9721 | -5.0569 | 2.2065 | 0.0585 | 0.0585 | 4.6730 |
| Trichostatin A | HCC1806 | -2.3010 | 0.9690 | -4.9315 | -4.9267 | -5.0104 | 2.1805 | 0.0119 | 0.0119 | 4.6628 |
| Trichostatin A | HCC1937 | -2.3010 | 0.9829 | -4.6870 | -4.6441 | -4.8525 | 1.4350 | 0.0659 | 0.0663 | 5.3981 |