Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Ixabepilone | SUM52PE | -4.4045 | 0.8127 | -8.4715 | -8.2024 | -8.8825 | 0.8237 | 0.1911 | 0.2049 | 4.0147 |
| Trametinib | SUM52PE | -4.7773 | 0.8128 | -7.8363 | -4.7773 | -7.5320 | 2.8210 | 0.6513 | 0.6513 | 7.8430 |
| Gefitinib | MB 157 | -4.4776 | 0.8135 | -4.7573 | -4.7572 | -5.3766 | 1.3280 | 0.0000 | 0.2983 | 7.7218 |
| Cisplatin | MDA-MB-468 | -3.6021 | 0.8140 | -5.0396 | -5.0399 | -5.4605 | 1.1090 | 0.0000 | 0.0250 | 6.3087 |
| Ispinesib | ZR-75-1 | -4.4776 | 0.8141 | -5.9411 | -5.9408 | -6.8200 | 0.4124 | 0.0000 | 0.1998 | 6.2880 |
| Gefitinib | HCC1806 | -4.4776 | 0.8141 | -5.0403 | -5.0403 | -5.3864 | 0.5684 | 0.0000 | 0.2892 | 7.4082 |
| Tozasertib | BT-474 | -4.0000 | 0.8143 | -4.4178 | -4.4177 | -5.1819 | 1.5550 | 0.0000 | 0.1831 | 7.9621 |
| NU6102 | UACC-812 | -4.1759 | 0.8145 | -4.5294 | -4.5294 | -4.5361 | 4.0000 | 0.0000 | 0.0371 | 7.6594 |
| (Z)-4-Hydroxytamoxifen | ZR75B | -3.7773 | 0.8147 | -4.2372 | -4.2372 | -4.7488 | 0.8060 | 0.0000 | 0.2987 | 7.6699 |
| Triciribine | BT-483 | -4.4776 | 0.8148 | -6.4496 | -4.4776 | -7.6168 | 0.3389 | 0.4704 | 0.5640 | 7.1257 |
| Triciribine | HCC1395 | -4.4776 | 0.8151 | -4.3237 | -4.4776 | -5.8158 | 0.2974 | 0.1533 | 0.5989 | 7.6593 |
| Gemcitabine | CAMA-1 | -3.8416 | 0.8152 | -7.2376 | -3.8416 | -6.5058 | 0.5254 | 0.6609 | 0.6664 | 7.2283 |
| Vinorelbine | HCC3153 | -4.3335 | 0.8153 | -7.5355 | -7.4557 | -7.5455 | 3.9990 | 0.2594 | 0.2594 | 4.9844 |
| Etoposide | MDA-MB-175-VII | -3.4776 | 0.8153 | -4.4210 | -3.4776 | -4.1525 | 0.7104 | 0.6756 | 0.7327 | 8.4739 |
| GSK1070916 | MDA-MB-134-VI | -4.4776 | 0.8155 | -4.5868 | -4.5868 | -5.5744 | 0.5597 | 0.0000 | 0.4864 | 7.9183 |
| Valproic acid | BT-20 | -1.8239 | 0.8160 | -2.3127 | -2.0752 | -2.4689 | 3.2920 | 0.2469 | 0.2785 | 7.8380 |
| AG1478 | HCC202 | -3.7773 | 0.8163 | -5.1303 | -4.8364 | -5.8491 | 0.9804 | 0.2192 | 0.2629 | 6.9668 |
| MG-132 | HCC1806 | -4.1759 | 0.8164 | -6.2219 | -6.2185 | -6.3075 | 2.7660 | 0.1127 | 0.1127 | 5.5285 |
| Docetaxel | MDA-MB-175-VII | -5.0000 | 0.8165 | -8.0975 | -5.0000 | -7.8058 | 2.7620 | 0.7630 | 0.7630 | 7.7847 |
| GSK923295 | HCC1143 | -4.4776 | 0.8172 | -7.1321 | -5.3503 | -7.1299 | 1.0993 | 0.5082 | 0.5099 | 7.0065 |
| Bosutinib | BT-474 | -4.0000 | 0.8176 | -5.4900 | -5.2670 | -5.8510 | 1.1260 | 0.2199 | 0.2359 | 7.0213 |
| Nutlin 3a | SUM185PE | -4.1759 | 0.8178 | -4.2760 | -4.2760 | -4.5962 | 1.5670 | 0.0000 | 0.4107 | 8.0758 |
| Tozasertib | MDA-MB-453 | -4.0000 | 0.8180 | -4.7763 | -4.7762 | -5.2841 | 0.7487 | 0.0000 | 0.2078 | 6.9240 |
| CPT-11 | HCC1419 | -4.0696 | 0.8181 | -3.9937 | -4.0696 | -4.5697 | 1.3440 | 0.0001 | 0.5585 | 8.6347 |
| Nutlin 3a | UACC-812 | -4.1759 | 0.8182 | -4.8178 | -4.5095 | -5.3750 | 1.0490 | 0.2625 | 0.3916 | 7.5355 |