Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| IKK16 | MDA-MB-436 | -4.1759 | 0.9899 | -5.4689 | -5.4692 | -5.5589 | 2.7430 | 0.0000 | 0.0003 | 6.5174 |
| IKK16 | CAMA-1 | -4.1759 | 0.9341 | -5.4409 | -5.4409 | -5.5702 | 2.7570 | 0.0000 | 0.0003 | 6.4513 |
| Fascaplysin | SUM159PT | -4.4776 | 0.9625 | -6.3636 | -6.3633 | -6.4005 | 1.8710 | 0.0000 | 0.0003 | 6.0962 |
| GSK1838705A | BT-549 | -4.1759 | 0.9516 | -5.2199 | -5.2198 | -5.2460 | 3.2270 | 0.0000 | 0.0004 | 7.3305 |
| IKK16 | MDA-MB-157 | -4.1759 | 0.9907 | -5.5299 | -5.5303 | -5.7266 | 2.4950 | 0.0000 | 0.0004 | 6.5296 |
| Bortezomib | HCC38 | -3.7773 | 0.9900 | -7.1958 | -7.1957 | -7.2796 | 3.4400 | 0.0004 | 0.0004 | 3.6395 |
| Vorinostat | SUM149PT | -1.7282 | 0.9920 | -3.9272 | -3.9268 | -4.0666 | 1.5390 | 0.0000 | 0.0004 | 5.2120 |
| Sunitinib | MX1 | -3.7773 | 0.9657 | -5.0223 | -5.0223 | -5.2285 | 2.7100 | 0.0000 | 0.0004 | 6.3318 |
| Imatinib | HCC1937 | -3.2480 | 0.9771 | -4.5720 | -4.5718 | -4.6962 | 2.4660 | 0.0000 | 0.0005 | 6.3870 |
| Imatinib | UACC-893 | -3.2480 | 0.9798 | -4.5520 | -4.5520 | -4.7819 | 2.5830 | 0.0000 | 0.0005 | 6.4846 |
| Imatinib | HCC2185 | -3.2480 | 0.9751 | -4.4870 | -4.4872 | -4.7372 | 3.1400 | 0.0003 | 0.0005 | 6.4589 |
| Vorinostat | HCC70 | -1.7282 | 0.9938 | -4.1322 | -4.1327 | -4.4808 | 1.3560 | 0.0000 | 0.0005 | 5.0455 |
| GSK1838705A | SUM185PE | -4.1759 | 0.9364 | -5.3819 | -5.3821 | -5.6140 | 2.6910 | 0.0000 | 0.0006 | 6.4731 |
| LBH589 | HCC1806 | -4.4776 | 0.9872 | -6.7156 | -6.7160 | -6.8511 | 1.4270 | 0.0000 | 0.0006 | 5.2350 |
| LBH589 | SUM159PT | -4.4776 | 0.9636 | -6.8996 | -6.8992 | -6.9383 | 1.3160 | 0.0000 | 0.0006 | 4.9535 |
| Fascaplysin | HCC70 | -4.4776 | 0.9766 | -6.5836 | -6.5841 | -6.9057 | 1.5250 | 0.0000 | 0.0006 | 5.2074 |
| NSC 663284 | UACC-893 | -3.7773 | 0.9778 | -5.1113 | -5.1116 | -5.4701 | 2.4310 | 0.0000 | 0.0006 | 6.3380 |
| Sunitinib | HCC1428 | -3.7773 | 0.9792 | -5.0478 | -5.0479 | -5.2565 | 2.5880 | 0.0000 | 0.0006 | 6.4400 |
| Imatinib | SUM225CWN | -3.2480 | 0.9795 | -4.6485 | -4.6481 | -4.8764 | 2.4335 | 0.0000 | 0.0006 | 6.5728 |
| Imatinib | HCC1428 | -3.2480 | 0.9867 | -4.5310 | -4.5302 | -4.7440 | 2.5995 | 0.0000 | 0.0007 | 6.6634 |
| Imatinib | AU565 | -3.2480 | 0.9768 | -4.6470 | -4.6466 | -4.7322 | 2.2870 | 0.0000 | 0.0007 | 6.4509 |
| Imatinib | HCC1143 | -3.2480 | 0.9749 | -4.5030 | -4.5032 | -4.5783 | 3.5030 | 0.0006 | 0.0007 | 6.7375 |
| Imatinib | HCC70 | -3.2480 | 0.9722 | -4.5260 | -4.5261 | -4.7307 | 2.4460 | 0.0000 | 0.0007 | 6.5545 |
| Vorinostat | MDA-MB-361 | -1.7282 | 0.9885 | -3.9522 | -3.9523 | -4.2812 | 1.5620 | 0.0002 | 0.0007 | 5.1490 |
| Fascaplysin | 184A1 | -4.4776 | 0.9829 | -6.3051 | -6.3045 | -6.4382 | 2.4270 | 0.0007 | 0.0007 | 5.9730 |