LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trametinib | 180703_BG_10 | 3160 | 0.0269 | 69 | 18 | 7 | 12 | Trametinib | 0.031603332 | treatment | 72 | 3 | MCF10A-GM_2 | 87 | 0.0268 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00501 | 0.2311 |
| Trametinib | 180614_BG_03 | 1792 | 0.0301 | 36 | 19 | 4 | 22 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_4 | 55 | 0.0298 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00978 | 0.1788 |
| Trametinib | 180703_BG_12 | 3489 | 0.0192 | 47 | 21 | 10 | 5 | Trametinib | 0.031603332 | treatment | 72 | 3 | MCF10A-GM_8 | 68 | 0.0191 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01268 | 0.2623 |
| Etoposide | 180703_BG_11 | 1710 | 0.1078 | 182 | 22 | 14 | 16 | Etoposide | 9.98 | treatment | 72 | 3 | MCF10A-GM_6 | 204 | 0.1066 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.07478 | 0.0542 |
| Trametinib | 180614_BG_02 | 1807 | 0.0377 | 48 | 22 | 14 | 14 | Trametinib | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_3 | 70 | 0.0373 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01730 | 0.1811 |
| Etoposide | 180614_BG_03 | 986 | 0.1017 | 86 | 23 | 14 | 4 | Etoposide | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_5 | 109 | 0.0995 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.07955 | 0.0246 |
| Etoposide | 180703_BG_10 | 1543 | 0.0530 | 61 | 24 | 4 | 15 | Etoposide | 9.98 | treatment | 72 | 3 | MCF10A-GM_1 | 85 | 0.0522 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.02041 | 0.0271 |
| Trametinib | 180703_BG_12 | 3092 | 0.0297 | 70 | 24 | 9 | 5 | Trametinib | 0.031603332 | treatment | 72 | 3 | MCF10A-GM_7 | 94 | 0.0295 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00230 | 0.2243 |
| Etoposide | 180703_BG_10 | 1445 | 0.0571 | 61 | 25 | 4 | 19 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_2 | 86 | 0.0562 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.02437 | 0.0103 |
| Etoposide | 180703_BG_10 | 1668 | 0.0425 | 48 | 25 | 8 | 20 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_3 | 73 | 0.0419 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.01013 | 0.0476 |
| Vorinostat | 180614_BG_02 | 2488 | 0.0364 | 67 | 26 | 7 | 8 | Vorinostat | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_2 | 93 | 0.0360 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01604 | 0.2731 |
| Trametinib | 180614_BG_03 | 1982 | 0.0360 | 47 | 26 | 10 | 19 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_6 | 73 | 0.0355 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01553 | 0.2070 |
| Trametinib | 180614_BG_02 | 2043 | 0.0400 | 57 | 27 | 8 | 13 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_2 | 84 | 0.0395 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01950 | 0.2156 |
| Trametinib | 180703_BG_11 | 3509 | 0.0363 | 104 | 27 | 14 | 12 | Trametinib | 0.031603332 | treatment | 72 | 3 | MCF10A-GM_6 | 131 | 0.0360 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.00419 | 0.2641 |
| Etoposide | 180703_BG_12 | 1707 | 0.0508 | 63 | 27 | 12 | 4 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_9 | 90 | 0.0501 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.01828 | 0.0537 |
| Etoposide | 180703_BG_11 | 1602 | 0.1137 | 175 | 27 | 6 | 8 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_4 | 202 | 0.1120 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.08017 | 0.0369 |
| Vorinostat | 180614_BG_02 | 1234 | 0.0436 | 28 | 27 | 10 | 16 | Vorinostat | 9.98 | treatment | 72 | 1 | MCF10A-GM_1 | 55 | 0.0427 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02267 | 0.0800 |
| Etoposide | 180703_BG_11 | 1760 | 0.0979 | 161 | 27 | 14 | 17 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_6 | 188 | 0.0965 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.06471 | 0.0619 |
| Trametinib | 180614_BG_02 | 1685 | 0.0366 | 35 | 28 | 4 | 17 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_1 | 63 | 0.0360 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01605 | 0.1619 |
| Palbociclib | 180622_BG_6 | 1487 | 0.0795 | 98 | 28 | 9 | 10 | Palbociclib | 10.01326667 | treatment | 72 | 2 | MCF10A-GM_2 | 126 | 0.0781 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.05199 | 0.1349 |
| Trametinib | 180614_BG_03 | 2093 | 0.0328 | 42 | 28 | 14 | 12 | Trametinib | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_6 | 70 | 0.0324 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01237 | 0.2225 |
| Trametinib | 180614_BG_04 | 2091 | 0.0519 | 85 | 28 | 10 | 5 | Trametinib | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_8 | 113 | 0.0513 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.03127 | 0.2223 |
| Trametinib | 180614_BG_03 | 1942 | 0.0529 | 79 | 28 | 14 | 7 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_6 | 107 | 0.0522 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.03223 | 0.2012 |
| Trametinib | 180614_BG_04 | 1649 | 0.0690 | 91 | 29 | 8 | 13 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_8 | 120 | 0.0678 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.04784 | 0.1560 |
| Etoposide | 180703_BG_12 | 1778 | 0.0632 | 89 | 29 | 4 | 3 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_7 | 118 | 0.0622 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.03044 | 0.0646 |