LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 66.21 | 12.8 | 0.0293 | 0.0275 | 0.0599 | 0.1396 | 5.0000 | 0.3328 |
| MCF 10A-H2B-mCherry | Palbociclib | 76.56 | 11.8 | 7.1386 | 8.822 | -0.1401 | -0.8206 | 5.0000 | 0.0720 |
| MCF 10A-H2B-mCherry | Vorinostat | 62.27 | 12.8 | 3.9882 | 3.9503 | 0.0256 | 0.0310 | 5.0000 | 0.1237 |
| MCF 10A-H2B-mCherry | Trametinib | 70.65 | 11.8 | 0.0304 | 0.028 | 0.0121 | 0.1724 | 5.0000 | 0.3478 |
| MCF 10A-H2B-mCherry | Vorinostat | 68.68 | 11.8 | 4.1522 | 4.1031 | 0.0493 | 0.0341 | 5.0000 | 0.1469 |
| MCF 10A-H2B-mCherry | Vorinostat | 66.21 | 12.8 | 3.8725 | 3.7635 | 0.0749 | 0.0914 | 5.0000 | 0.1148 |
| MCF 10A-H2B-mCherry | Trametinib | 72.62 | 11.8 | 0.0314 | 0.0301 | -0.0207 | 0.1090 | 5.0000 | 0.3790 |
| MCF 10A-H2B-mCherry | Taxol | 82.47 | 11.8 | 0.0008 | 0.0008 | -0.4992 | -0.3263 | 5.0000 | 0.8223 |
| MCF 10A-H2B-mCherry | Taxol | 88.39 | 11.8 | 0.0006 | 0.0007 | -0.5000 | -0.6119 | 5.0000 | 1.1071 |
| MCF 10A-H2B-mCherry | Trametinib | 68.68 | 11.8 | 0.0271 | 0.0263 | 0.0288 | 0.0625 | 5.0000 | 0.3792 |
| MCF 10A-H2B-mCherry | Vorinostat | 64.24 | 12.8 | 3.8453 | 3.8311 | 0.0082 | 0.0174 | 5.0000 | 0.1712 |
| MCF 10A-H2B-mCherry | Trametinib | 60.30 | 12.8 | 0.0236 | 0.0232 | 0.0787 | 0.0863 | 5.0000 | 0.3806 |
| MCF 10A-H2B-mCherry | Trametinib | 64.24 | 12.8 | 0.0312 | 0.0294 | 0.0440 | 0.1264 | 5.0000 | 0.3304 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.30 | 12.8 | 5.1736 | 6.2528 | -0.1534 | -0.4901 | 5.0000 | 0.1348 |
| MCF 10A-H2B-mCherry | Palbociclib | 84.44 | 11.8 | 7.8009 | 9.9225 | -0.0850 | -1.0000 | 5.0000 | 0.0239 |
| MCF 10A-H2B-mCherry | Dasatinib | 62.27 | 12.8 | 4.3975 | 5.6665 | -0.1761 | -0.4952 | 5.0000 | 0.1176 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.50 | 11.8 | 6.7725 | 8.2243 | -0.3199 | -0.8211 | 5.0000 | 0.0725 |
| MCF 10A-H2B-mCherry | Etoposide | 70.65 | 11.8 | 0.374 | 0.4184 | -0.4742 | -0.3943 | 5.0000 | 0.6342 |
| MCF 10A-H2B-mCherry | Taxol | 84.44 | 11.8 | 0.0007 | 0.0008 | -0.5000 | -0.4460 | 5.0000 | 0.9331 |
| MCF 10A-H2B-mCherry | Dasatinib | 64.24 | 12.8 | 7.076 | 8.823 | -0.3039 | -1.0000 | 5.0000 | 0.1184 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.53 | 11.8 | 6.8 | 7.9008 | -0.2637 | -0.6220 | 5.0000 | 0.0666 |
| MCF 10A-H2B-mCherry | Dasatinib | 58.33 | 12.8 | 4.7813 | 6.0034 | -0.2173 | -0.5391 | 5.0000 | 0.1370 |
| MCF 10A-H2B-mCherry | Vorinostat | 70.65 | 11.8 | 4.0002 | 3.6262 | 0.0895 | 0.1990 | 4.9999 | 0.1728 |
| MCF 10A-H2B-mCherry | Taxol | 72.62 | 11.8 | 0.0011 | 0.0012 | -0.4139 | -0.4353 | 4.9999 | 0.9083 |
| MCF 10A-H2B-mCherry | Etoposide | 88.39 | 11.8 | 0.5141 | 0.6076 | -0.3934 | -0.3430 | 4.9994 | 0.4871 |