Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
5-FU
TYMS
TYMS
 43.5628 98.8715 100.0000 -0.6126 -0.4736 -0.0711 -0.8532 -0.6532 -0.1200 0.5225 0.5967 0.7832 0.3295 0.4853 0.6100 100.0000 100.0000 100.0000
Taxol
TUBB
TUBB
 0.0078 0.0104 0.0155 -0.5505 -0.2204 0.0319 -0.5168 -0.1393 0.1113 1.6357 2.0915 3.1238 0.5399 0.6855 0.9358 0.0096 0.0111 0.0153
Docetaxel
TUBB
TUBB
 0.0022 0.0051 0.0098 -0.3944 -0.0464 0.1697 -0.4257 -0.0477 0.1373 1.4024 1.6746 2.3040 0.4979 0.6215 0.8198 0.0027 0.0049 0.0080
Ixabepilone
TUBB
TUBB
 0.0045 0.0114 0.0487 -0.9765 -0.9460 -0.8485 -0.9892 -0.7196 -0.5742 0.3937 0.7623 1.6684 0.6842 0.8505 0.9658 0.0102 0.0892 0.7025
Vinorelbine
TUBB
TUBB
 0.0079 0.0130 0.0470 -0.9358 -0.8653 -0.6758 -1.0000 -0.5683 -0.3360 0.3815 2.2644 3.6055 0.6197 0.8320 1.0409 0.0132 0.0302 0.9743
Epirubicin
TOP2
TOP
 0.2120 0.3019 0.4930 -0.9915 -0.9463 -0.8152 -0.8492 -0.7437 -0.6556 0.9325 1.4047 2.1457 0.6134 0.7438 0.8467 0.3985 0.6015 1.3650
ICRF-193
TOP2
TOP
 8.5852 100.0000 100.0000 0.3561 0.5910 0.6710 0.2252 0.4446 0.6698 0.1440 0.6745 1.5658 0.1152 0.1622 0.2393 0.3708 3.7956 100.0000
Etoposide
TOP2
TOP
 1.1610 2.9708 7.6285 -0.6938 -0.4841 -0.2079 -0.7406 -0.5842 -0.4690 0.5531 0.8108 1.2247 0.3770 0.4769 0.5711 4.4274 7.6731 19.6965
Doxorubicin
TOP2
TOP
 0.1488 0.2099 0.7023 -0.9456 -0.8552 -0.5483 -0.8723 -0.7083 -0.3772 1.0561 1.4782 2.5260 0.5209 0.6697 0.8073 0.2444 0.4713 1.2126
Topotecan
TOP1
TOP
 0.0324 0.1223 0.4672 -0.7615 -0.5906 -0.2740 -0.8265 -0.6901 -0.4582 0.5573 0.7931 1.1373 0.5801 0.7088 0.8375 0.0774 0.7078 1.2170
CPT-11
TOP1
TOP
 3.1544 10.7270 20.8553 -0.5980 -0.2192 0.1666 -0.9688 -0.6234 -0.1292 0.8799 1.3528 1.8883 0.1220 0.2195 0.2928 7.3583 23.7091 36.8667
Bosutinib
Src
nRTK
 1.2187 1.7497 4.1420 -0.6727 -0.4219 -0.1512 -0.7662 -0.4684 -0.1288 0.9612 1.6575 1.9534 0.3079 0.3819 0.4639 1.7722 2.5602 5.3523
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
Bortezomib
Proteasome
Proteasome
 0.0169 0.0283 0.0758 -0.9074 -0.8026 -0.7299 -0.9162 -0.8011 -0.7357 1.1703 1.8347 2.7508 0.9093 1.0406 1.1781 0.0266 0.0496 0.1485
MG-132
Proteasome
Proteasome
 0.1071 0.1768 0.5078 -0.8632 -0.7505 -0.5413 -0.8499 -0.6667 -0.5123 1.5044 2.4128 3.5768 0.6530 0.7329 0.8677 0.1559 0.2469 1.0059
Disulfiram
Proteasome
Proteasome
 0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000
Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
 0.4036 0.5478 1.0248 -0.8567 -0.7928 -0.6682 -0.8570 -0.7958 -0.6543 1.7769 2.1873 3.5139 0.5265 0.6392 0.6811 0.6073 0.7378 1.6091
CGC-11047
Polyamine analogue
N/A
 43.1451 85.4630 100.0000 -0.8722 -0.7234 -0.2437 -1.0000 -0.9172 -0.4365 0.4134 0.5735 1.1488 0.3172 0.3971 0.4905 94.6485 100.0000 100.0000
GSK461364
PLK1
PLK
 0.0087 0.0183 0.0805 -0.6111 -0.4222 -0.2111 -0.4745 -0.3080 -0.0919 2.4728 2.7172 4.9263 0.4701 0.6125 0.7345 0.0105 0.0265 0.3325
TCS PIM-1 1
Pim kinase
PIM
 90.9415 100.0000 100.0000 0.4852 0.6734 0.7827 0.3505 0.5918 0.7255 0.0000 1.5057 4.5238 0.0404 0.0756 0.1063 26.3980 73.0639 100.0000
Omipalisib
PI3K
PI3K
 0.0049 0.0154 0.0397 -0.8281 -0.5752 -0.4164 -0.8004 -0.5070 -0.2908 0.6200 0.7592 0.9464 0.6332 0.8101 0.9689 0.0158 0.0370 0.0945
AS-252424
PI3K
PI3K
 19.5544 36.2256 100.0000 0.2865 0.4240 0.5918 -0.9991 0.2157 0.5619 0.3148 0.6846 2.7243 0.0770 0.1059 0.1601 6.6689 89.5846 100.0000
Dactolisib
PI3K
PI3K
 0.1885 0.5181 100.0000 0.2549 0.5042 0.6208 0.2262 0.4314 0.5885 0.0000 2.2633 4.9147 0.2133 0.2744 0.3494 0.1148 0.3521 100.0000
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