Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
PD 98059
MEK
MAPK
 100.0000 100.0000 100.0000 0.5235 0.6650 0.8191 -0.1517 0.5395 0.8149 0.0000 0.2473 0.7779 0.0463 0.0842 0.1501 32.4005 100.0000 100.0000
Ribavirin
N/A
N/A
 100.0000 100.0000 100.0000 0.6045 0.7146 0.9546 0.4725 0.6701 0.9546 0.0000 0.0000 0.9838 0.0119 0.0416 0.0703 50.4745 100.0000 100.0000
Valproic acid
HDAC
HDAC
 100.0000 100.0000 100.0000 -0.8969 -0.6820 -0.4277 -0.5381 -0.3207 -0.1180 1.1443 1.2884 1.4704 0.1935 0.2464 0.2891 100.0000 100.0000 100.0000
FTase Inhibitor I
Ftase
MAPK
 100.0000 100.0000 100.0000 0.7715 0.8851 0.9752 0.7468 0.8851 0.9752 0.0000 0.0000 0.0000 0.0099 0.0556 0.0941 100.0000 100.0000 100.0000
Dichloroacetate
PDK
PDK
 100.0000 100.0000 100.0000 0.8082 0.8801 0.9216 0.7946 0.8670 0.9296 0.0000 0.0000 0.2064 0.0234 0.0440 0.0744 58.3872 100.0000 100.0000
PS-1145
IKK
NFKB
 100.0000 100.0000 100.0000 0.8452 0.9304 0.9718 0.8353 0.9304 0.9695 0.0000 0.0000 0.8067 -0.0033 0.0200 0.0533 100.0000 100.0000 100.0000
Cetuximab
EGFR
ErbB
 100.0000 100.0000 100.0000 0.7284 0.8755 0.9754 0.5964 0.8555 0.9754 0.0000 0.0000 0.7916 -0.0099 0.0234 0.0674 3.7461 100.0000 100.0000
Nilotinib
ABL
nRTK
 100.0000 100.0000 100.0000 0.7849 0.9109 1.0055 0.7841 0.9109 1.0055 0.0000 0.0000 0.7234 0.0029 0.0487 0.0775 73.6076 100.0000 100.0000
TCS PIM-1 1
Pim kinase
PIM
 90.9415 100.0000 100.0000 0.4852 0.6734 0.7827 0.3505 0.5918 0.7255 0.0000 1.5057 4.5238 0.0404 0.0756 0.1063 26.3980 73.0639 100.0000
Vorinostat
HDAC
HDAC
 72.1503 100.0000 100.0000 -0.8970 -0.8099 -0.5591 -0.9320 -0.8403 -0.5970 1.0273 1.3201 1.6251 0.4794 0.5820 0.7389 100.0000 100.0000 100.0000
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
SB-3CT
MMP2/9
MMP
 69.9094 100.0000 100.0000 0.4441 0.6795 0.8316 -0.1049 0.6210 0.7846 0.0670 0.6905 2.4960 0.0290 0.0754 0.1306 27.8608 93.1362 100.0000
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
FR180204
ERK1/2
MAPK
 56.2203 100.0000 100.0000 0.4862 0.6317 0.8238 -0.1433 0.2500 0.7055 0.0180 0.6403 1.9539 0.0470 0.0722 0.1058 65.9938 100.0000 100.0000
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
5-FU
TYMS
TYMS
 43.5628 98.8715 100.0000 -0.6126 -0.4736 -0.0711 -0.8532 -0.6532 -0.1200 0.5225 0.5967 0.7832 0.3295 0.4853 0.6100 100.0000 100.0000 100.0000
CGC-11047
Polyamine analogue
N/A
 43.1451 85.4630 100.0000 -0.8722 -0.7234 -0.2437 -1.0000 -0.9172 -0.4365 0.4134 0.5735 1.1488 0.3172 0.3971 0.4905 94.6485 100.0000 100.0000
Baicalein
Lipoxygenase
Metabolism
 41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
 36.5873 68.4588 100.0000 -0.7737 -0.2023 0.2203 -0.7439 -0.3900 0.2345 0.6570 1.9429 3.4993 0.1339 0.2188 0.2978 54.8881 71.4700 100.0000
Lapatinib
EGFR/HER2
ErbB
 31.2806 100.0000 100.0000 0.4954 0.7950 0.9113 0.2428 0.7519 0.9066 0.0000 0.2457 1.3492 0.0247 0.0703 0.1302 1.5972 63.5403 100.0000
PD184352
MEK
MAPK
 31.0822 100.0000 100.0000 0.4258 0.7584 0.9084 -0.2272 0.7139 0.9084 0.0000 0.0524 0.4766 0.0368 0.0888 0.1432 63.7076 100.0000 100.0000
Carboplatin
DNA cross-linker
DNA cross-linker
 30.4522 52.4276 91.0569 -0.9081 -0.7672 -0.5844 -0.9460 -0.8644 -0.7390 1.2433 1.6402 2.1619 0.2714 0.3706 0.4859 52.1319 91.7409 100.0000
Purvalanol A
CDK1
CDK
 25.2896 54.7310 100.0000 0.0757 0.5333 0.7416 -0.0675 0.5068 0.7450 1.0817 2.5000 4.2404 0.0335 0.0774 0.1767 18.1854 35.4887 52.3768
AS-252424
PI3K
PI3K
 19.5544 36.2256 100.0000 0.2865 0.4240 0.5918 -0.9991 0.2157 0.5619 0.3148 0.6846 2.7243 0.0770 0.1059 0.1601 6.6689 89.5846 100.0000
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