Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7804.016 | uM | inf | 6.52220 | 0.6730 | 0.7956 | 5.0000 | 0.0568 | 0.6718 | 2.3055 | ||
| SUM149PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 10819.15 | uM | 69.42850 | 464.22560 | 0.6339 | -1.0000 | 0.5782 | 0.0678 | 0.9396 | 2.1256 | ||
| SUM149PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 11937.16 | uM | 84.87320 | 21.4970 | 0.5288 | 0.3549 | 0.9008 | 0.0794 | 0.9443 | 2.4144 | ||
| BT-549 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9024.016 | uM | inf | 5.49290 | 0.9158 | 0.9125 | 0.9479 | 0.0127 | 0.6896 | 3.2430 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9420.132 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0075 | -0.0001 | 0.3309 | ||
| BT-549 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7803.016 | uM | inf | 999.99990 | 0.8001 | 0.2753 | 0.5655 | 0.0269 | 0.7925 | 2.8300 | ||
| HCC38 | TNBC | Basal B | Ibandronate | FDPS | 11850.143 | uM | 58.12590 | 78.37930 | -0.4564 | -0.4499 | 2.1468 | 0.3429 | 0.9952 | 2.1044 | ||
| SK-BR-3 | HER2amp | Luminal | Nelfinavir | 12999.174 | uM | 7.55250 | 13.51060 | -0.7021 | -1.0000 | 1.8890 | 0.2038 | 0.9850 | 0.8315 | |||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7907.018 | uM | 1.07690 | 84.78930 | -0.8313 | -1.0000 | 0.2516 | 0.7516 | 0.8193 | 1.5217 | ||
| CAMA-1 | HR+ | Luminal | Methylglyoxal | 13157.184 | uM | 532.38820 | 1000.00000 | -0.9916 | -0.5508 | 1.1782 | 0.3945 | 0.8666 | 0.8492 | |||
| HCC1806 | TNBC | Basal A | Nelfinavir | 12702.174 | uM | 8.77290 | 11.30080 | -0.8571 | -0.8812 | 4.0129 | 0.1752 | 0.9941 | 1.8506 | |||
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7836.016 | uM | 33.93490 | 143.9580 | -0.0804 | -1.0000 | 0.7602 | 0.1638 | 0.9872 | 1.5669 | ||
| SUM149PT | TNBC | Basal B | Ibandronate | FDPS | 10819.143 | uM | 256.9290 | 999.98650 | 0.0594 | -0.6639 | 0.6217 | 0.1984 | 0.9772 | 2.2570 | ||
| SUM149PT | TNBC | Basal B | Ibandronate | FDPS | 11937.143 | uM | 263.80820 | 1000.00000 | 0.0199 | -0.6889 | 0.6500 | 0.1784 | 0.9858 | 2.3169 | ||
| MDA-MB-415 | HR+ | Luminal | Ibandronate | FDPS | 10938.143 | uM | 46.92680 | 98.68990 | -0.8792 | -0.9200 | 1.4041 | 0.4882 | 0.9554 | 1.0173 | ||
| 600MPE | HR+ | Luminal | Methylglyoxal | 13091.184 | uM | 541.6520 | 823.99310 | -0.9999 | -0.9709 | 2.5719 | 0.6677 | 0.9952 | 0.8014 | |||
| MDA-MB-415 | HR+ | Luminal | Ibandronate | FDPS | 12333.143 | uM | 48.64890 | 54.3240 | -0.4546 | -0.3681 | 4.9998 | 0.4351 | 0.9371 | 0.6265 | ||
| MCF 10A | NM | Basal B | Ribavirin | 15392.211 | uM | inf | 1000.00000 | 0.6244 | 0.0123 | 0.2385 | 0.1289 | 0.6395 | 2.9667 | |||
| HCC1143 | TNBC | Basal A | Methylglyoxal | 13099.184 | uM | 202.87190 | 579.86070 | -0.9991 | -1.0000 | 1.0461 | 0.7426 | 0.9727 | 1.0279 | |||
| EFM-192C | HER2amp | Luminal | Ribavirin | 15292.211 | uM | inf | inf | 0.6694 | 0.6694 | 0.0000 | 0.1738 | 0.0209 | 1.7715 | |||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7904.018 | uM | 3.02880 | 158.54660 | -0.7754 | -1.0000 | 0.2776 | 0.6540 | 0.7761 | 1.4056 | ||
| 184A1 | NM | Basal | Mebendazole | 12684.174 | uM | inf | 0.36667 | 0.5334 | 0.5745 | 5.0000 | 0.1723 | 0.9699 | 1.4645 | |||
| CAMA-1 | HR+ | Luminal | Nelfinavir | 12647.174 | uM | 4.63860 | 8.64280 | -0.9213 | -1.0000 | 1.7654 | 0.3605 | 0.8914 | 0.9362 | |||
| HCC70 | TNBC | Basal A | Torkinib | 15390.211 | uM | -inf | 0.00003 | -0.9960 | -0.9803 | 0.5245 | 1.8586 | 0.9905 | 0.5021 | |||
| HCC1428 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9294.019 | uM | 0.86738 | 57.77570 | -0.3357 | -1.0000 | 0.2617 | 0.4741 | 0.9102 | 0.8608 |