Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 14918.203 | uM | 0.00872 | 0.01466 | -0.9994 | -0.9980 | 2.1115 | 1.3233 | 0.9984 | 0.5296 | |
| MX1 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 14918.203 | uM | 0.00872 | 0.01466 | -0.9994 | -0.9980 | 2.1115 | 1.3233 | 0.9984 | 0.5296 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 9044.067 | uM | 0.01283 | 0.01597 | -1.0000 | -0.9908 | 4.9982 | 1.3236 | 0.7375 | 0.3210 | |
| BT-20 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14116.189 | uM | 0.01949 | 0.02399 | -0.9999 | -0.9133 | 4.9999 | 1.3281 | 0.7354 | 0.5416 | |
| BT-20 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14116.189 | uM | 0.01949 | 0.02399 | -0.9999 | -0.9133 | 4.9999 | 1.3281 | 0.7354 | 0.5416 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7538.05 | uM | 0.00192 | 0.00909 | -0.9534 | -0.8701 | 0.6494 | 1.3306 | 0.9780 | 0.5587 | |
| EFM-192B | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15288.203 | uM | 0.00623 | 0.01064 | -0.9838 | -0.9625 | 2.0041 | 1.3369 | 0.9980 | 0.7873 | |
| EFM-192B | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15288.203 | uM | 0.00623 | 0.01064 | -0.9838 | -0.9625 | 2.0041 | 1.3369 | 0.9980 | 0.7873 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14841.203 | uM | 0.00621 | 0.01122 | -0.9733 | -0.9729 | 1.8265 | 1.3380 | 0.9989 | 1.0330 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14841.203 | uM | 0.00621 | 0.01122 | -0.9733 | -0.9729 | 1.8265 | 1.3380 | 0.9989 | 1.0330 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10266.131 | uM | -inf | 0.00975 | -0.9900 | -1.0000 | 0.1117 | 1.3424 | 0.6662 | 0.8552 | |
| EFM-19 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15296.203 | uM | 0.00378 | 0.00648 | -0.9285 | -0.9001 | 1.9073 | 1.3477 | 0.9972 | 1.1208 | |
| EFM-19 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15296.203 | uM | 0.00378 | 0.00648 | -0.9285 | -0.9001 | 1.9073 | 1.3477 | 0.9972 | 1.1208 | |
| SUM159PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14921.203 | uM | 0.00175 | 0.00299 | -0.7142 | -0.7255 | 1.6650 | 1.3482 | 0.9972 | 3.0799 | |
| SUM159PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14921.203 | uM | 0.00175 | 0.00299 | -0.7142 | -0.7255 | 1.6650 | 1.3482 | 0.9972 | 3.0799 | |
| BT-20 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 5904.095 | uM | 0.00177 | 0.00213 | -0.9973 | -0.7751 | 4.9993 | 1.3519 | 0.9867 | 0.6537 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9469.011 | uM | 0.00436 | 0.00565 | -0.7427 | -0.6976 | 3.3673 | 1.3528 | 0.9958 | 1.1991 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9258.121 | uM | 0.00349 | 0.01125 | -0.9927 | -0.9212 | 0.8921 | 1.3529 | 0.9299 | 0.4800 | |
| HCC202 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7458.074 | uM | 0.02143 | 0.02670 | -0.9999 | -1.0000 | 5.0000 | 1.3545 | 0.9987 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7458.074 | uM | 0.02143 | 0.02670 | -0.9999 | -1.0000 | 5.0000 | 1.3545 | 0.9987 | 0.4138 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 13030.002 | uM | 0.00191 | 0.00244 | -0.8900 | -0.8727 | 4.1578 | 1.3615 | 0.9989 | 0.5732 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10643.087 | uM | 0.00172 | 0.00488 | -1.0000 | -0.9991 | 1.0559 | 1.3640 | 0.9987 | 0.6516 | |
| EFM-192A | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15284.203 | uM | 0.00168 | 0.00434 | -0.7916 | -0.8337 | 1.0336 | 1.3674 | 0.9953 | 0.6980 |