Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7432.095 | uM | 0.00090 | 0.00136 | -0.9922 | -0.9565 | 2.5808 | 1.5603 | 0.9988 | 0.8368 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 13030.002 | uM | 0.00092 | 0.00128 | -0.9104 | -0.8772 | 3.0709 | 1.3116 | 0.9975 | 0.5732 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| Hs 578T | TNBC | Basal B | Omipalisib | PI3K | PI3K | 7471.087 | uM | 0.00095 | 0.01694 | -0.9408 | -1.0000 | 0.3813 | 1.1700 | 0.910 | 0.5895 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7879.001 | uM | 0.00096 | 0.00101 | -0.3010 | -0.0757 | 2.6224 | 0.8576 | 0.9447 | 1.8589 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9469.121 | uM | 0.00096 | 0.00177 | -0.7010 | -0.7334 | 1.4902 | 1.4796 | 0.9951 | 1.1298 | |
| HCC1419 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7819.068 | uM | 0.00097 | 0.00953 | -0.9999 | -0.6956 | 0.3814 | 1.1819 | 0.8465 | 0.4460 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 10147.012 | uM | 0.00098 | 0.00091 | -0.1956 | 0.0632 | 1.9761 | 0.7030 | 0.8821 | 1.6544 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10470.087 | uM | 0.00098 | 0.00256 | -0.9996 | -1.0000 | 1.1390 | 1.4830 | 0.9905 | 0.3641 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 7849.001 | uM | 0.00104 | 0.00115 | -0.9115 | -0.3518 | 5.0000 | 1.0464 | 0.8751 | 0.5308 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| BT-483 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 10696.087 | uM | 0.00107 | 0.00675 | -0.8871 | -0.8807 | 0.5520 | 1.2219 | 0.9912 | 0.5247 | |
| SK-BR-3 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7912.068 | uM | 0.00112 | 0.00189 | -0.4187 | -0.3319 | 0.9812 | 1.1470 | 0.9516 | 0.5196 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7833.001 | uM | 0.00113 | 0.07446 | -0.7706 | -1.0000 | 0.2625 | 0.9401 | 0.7814 | 1.0468 | |
| CAMA-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5911.094 | uM | 0.00116 | 0.00147 | -0.9872 | -0.4078 | 2.5090 | 1.3193 | 0.6376 | 1.0146 | |
| HCC2185 | TNBC | Luminal | QNZ | NFkB | NFKB | 7462.096 | uM | 0.00116 | 0.00255 | -0.6368 | -0.6418 | 1.0495 | 1.2048 | 0.9957 | 0.3514 | |
| HCC1806 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 12702.002 | uM | 0.00118 | 0.00171 | -0.4526 | -0.4961 | 1.8445 | 1.0089 | 0.9954 | 1.8712 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7909.001 | uM | 0.00120 | 0.00121 | 0.2096 | -0.0127 | 5.0000 | 0.8306 | 0.6530 | 1.5909 | |
| HCC202 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7841.068 | uM | 0.00121 | 0.11539 | -0.9987 | -1.0000 | 0.2410 | 1.0741 | 0.8833 | 0.6440 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 9047.012 | uM | 0.00121 | 0.00198 | -0.2658 | -0.2622 | 0.8548 | 0.8904 | 0.9728 | 0.7549 | |
| BT-483 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 5908.069 | uM | 0.00124 | 0.00074 | 0.1221 | 0.1875 | 0.9066 | 0.6615 | 0.9618 | 0.6014 | |
| SK-BR-3 | HER2amp | Luminal | Torkinib | 15356.211 | uM | 0.00125 | 0.00492 | -0.3826 | -0.3333 | 0.3720 | 0.8953 | 0.9717 | 1.3112 | |||
| BT-474 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 5906.095 | uM | 0.00127 | 0.00167 | -0.9990 | -0.3324 | 1.8966 | 0.9953 | 0.6890 | 0.6731 |