Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9997.121 | 0.7056 | 0.4617 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9997.121 | 0.6053 | 0.2734 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9997.121 | 0.2081 | -0.5124 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9997.121 | 0.8975 | 0.8147 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9997.121 | 0.8778 | 0.7788 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9997.121 | 0.9840 | 0.9712 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9997.121 | 0.5905 | 0.2453 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9997.121 | 0.1652 | -0.6039 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9997.121 | 0.0272 | -0.9219 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9997.121 | 1.0034 | 1.0061 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9997.121 | 0.9923 | 0.9861 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9997.121 | 1.0909 | 1.1628 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9997.121 | 1.0333 | 1.0597 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9997.121 | 1.0316 | 1.0567 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9997.121 | 0.6110 | 0.2842 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9997.121 | 1.0363 | 1.0651 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9997.121 | 0.6801 | 0.4140 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9997.121 | 0.8470 | 0.7225 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9997.121 | 0.6581 | 0.3728 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9997.121 | 1.0273 | 1.0491 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9997.121 | 1.1243 | 1.2222 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9997.121 | 1.1261 | 1.2254 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9997.121 | 1.0633 | 1.1135 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9997.121 | 0.5022 | 0.0766 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9997.121 | 0.6055 | 0.2737 | 1.1121 |