Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AU565 | 3.16 | nM | 24 | hr | 469.42 | 121.81 | p-Akt | 100.82 | |
| Triciribine | T47D | 3.16 | nM | 6 | hr | 96.97 | 52.42 | p-Akt | 20.09 | |
| Triciribine | MCF 10A | 1.0 | nM | 24 | hr | 311.02 | 118.46 | p-Akt | 43.92 | |
| Triciribine | AU565 | 3.16 | nM | 6 | hr | 205.62 | 54.24 | p-Akt | 19.22 | |
| Triciribine | HCC1954 | 3.16 | nM | 24 | hr | 300.93 | 100.97 | p-Akt | 59.45 | |
| Triciribine | MCF 10A | 3.16 | nM | 24 | hr | 272.12 | 127.39 | p-Akt | 34.72 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 439.88 | 158.37 | p-Akt | 51.51 | |
| Triciribine | T47D | 0 (control) | 24 | hr | 186.87 | 92.32 | p-Akt | 71.34 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 109.11 | 47.87 | p-Akt | 21.01 | | |
| Triciribine | T47D | 1.0 | nM | 24 | hr | 146.78 | 89.33 | p-Akt | 59.46 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 237.48 | 78.12 | p-Akt | 40.18 | |
| Triciribine | AU565 | 1.0 | nM | 24 | hr | 484.33 | 118.39 | p-Akt | 103.66 | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 477.54 | 163.37 | p-Akt | 60.15 | | |
| Triciribine | MCF 10A | 3.16 | nM | 6 | hr | 404.45 | 155.90 | p-Akt | 44.15 | |
| Triciribine | AU565 | 1.0 | nM | 6 | hr | 225.05 | 59.35 | p-Akt | 21.63 | |
| Triciribine | HCC1954 | 1.0 | nM | 24 | hr | 295.65 | 96.48 | p-Akt | 59.73 | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 231.71 | 61.01 | p-Akt | 21.54 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 333.49 | 112.55 | p-Akt | 47.91 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 511.74 | 118.54 | p-Akt | 102.35 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 225.27 | 70.45 | p-Akt | 36.85 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 282.25 | 98.69 | p-Akt | 60.55 | | |
| Triciribine | T47D | 1.0 | nM | 6 | hr | 96.98 | 46.31 | p-Akt | 19.11 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 192.23 | 55.17 | p-Akt | 31.66 | |
| Triciribine | AU565 | 10.0 | nM | 6 | hr | 278.40 | 74.05 | p-Akt | 23.07 | |
| Triciribine | T47D | 3.16 | nM | 24 | hr | 157.47 | 91.95 | p-Akt | 63.67 | |