Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | T47D | 100.0 | nM | 6 | hr | 80.72 | 30.01 | p-S6 | 3.74 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 89.72 | 38.09 | p-S6 | 3.89 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 93.77 | 37.06 | p-S6 | 3.89 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 91.80 | 41.44 | p-S6 | 3.90 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 85.91 | 37.58 | p-S6 | 3.98 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 88.85 | 36.94 | p-S6 | 4.07 | |
| Dactolisib | T47D | 100.0 | nM | 6 | hr | 90.18 | 40.47 | p-S6 | 4.14 | |
| Dactolisib | T47D | 316.0 | nM | 6 | hr | 97.87 | 46.75 | p-S6 | 4.38 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 99.22 | 33.03 | p-S6 | 4.39 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 100.29 | 48.05 | p-S6 | 4.44 | |
| Dactolisib | T47D | 31.6 | nM | 6 | hr | 90.16 | 29.57 | p-S6 | 4.68 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 108.89 | 34.29 | p-S6 | 4.77 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 84.83 | 32.58 | p-4EBP1 | 4.80 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 115.90 | 38.54 | p-S6 | 4.85 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 118.48 | 37.34 | p-S6 | 4.86 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 90.13 | 33.66 | p-4EBP1 | 5.00 | |
| Dactolisib | T47D | 316.0 | nM | 24 | hr | 109.12 | 37.01 | p-S6 | 5.01 | |
| Torkinib | T47D | 133.0 | nM | 24 | hr | 119.60 | 41.42 | p-S6 | 5.06 | |
| Dactolisib | T47D | 3.16 | uM | 24 | hr | 125.73 | 47.33 | p-S6 | 5.11 | |
| Dactolisib | T47D | 31.6 | nM | 6 | hr | 97.27 | 52.91 | p-S6 | 5.12 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 116.01 | 40.48 | p-S6 | 5.28 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 309.38 | 126.66 | p-4EBP1 | 5.36 | |
| Torkinib | T47D | 562.0 | nM | 24 | hr | 120.85 | 41.75 | p-S6 | 5.37 | |
| Dactolisib | T47D | 3.16 | uM | 6 | hr | 101.02 | 45.77 | p-4EBP1 | 5.42 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 85.23 | 24.35 | p-4EBP1 | 5.42 | |