HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Gefitinib	MCF 10A	100.0	nM	24	hr	416.72	200.10	p-S6	651.75
GSK1059615	MCF 10A	10.0	nM	6	hr	453.23	198.94	p-S6	918.10
Gefitinib	MCF 10A	100.0	nM	24	hr	372.85	195.99	p-S6	350.71
Gefitinib	MCF 10A	31.6	nM	24	hr	408.64	195.12	p-S6	597.71
Gefitinib	MCF 10A	316.0	nM	24	hr	262.25	189.00	p-S6	404.58
Gefitinib	MCF 10A	31.6	nM	24	hr	351.27	188.69	p-S6	357.23
Gefitinib	MCF 10A	10.0	nM	24	hr	413.04	188.00	p-S6	584.31
GSK1059615	MCF 10A	100.0	nM	24	hr	401.51	187.40	p-S6	583.76
Gefitinib	MCF 10A	3.16	nM	6	hr	407.59	187.11	p-S6	480.67
GSK1059615	MCF 10A	31.6	nM	6	hr	411.99	186.56	p-S6	785.76
Torkinib	MCF 10A	31.6	nM	24	hr	415.92	185.17	p-4EBP1	126.98
Torkinib	MCF 10A	7.5	nM	6	hr	516.67	184.66	p-S6	775.89
Torkinib	MCF 10A	7.5	nM	24	hr	488.46	184.47	p-S6	594.52
GSK1059615	MCF 10A	3.16	nM	6	hr	446.31	184.25	p-S6	782.26
Torkinib	MCF 10A	31.6	nM	24	hr	530.47	184.23	p-S6	699.60
GSK1059615	MCF 10A	100.0	nM	6	hr	360.15	184.01	p-S6	712.09
Gefitinib	MCF 10A	10.0	nM	24	hr	371.59	183.06	p-S6	412.89
GSK1059615	MCF 10A	1.0	nM	6	hr	449.62	182.84	p-S6	658.02
Gefitinib	MCF 10A	316.0	nM	24	hr	296.12	182.11	p-S6	712.92
GSK1059615	MCF 10A	31.6	nM	6	hr	404.32	181.97	p-4EBP1	362.50
Torkinib	MCF 10A	1.78	nM	6	hr	479.13	181.71	p-S6	769.25
MK2206	MCF 10A	1.0	uM	24	hr	344.63	180.54	p-4EBP1	202.39
GSK1059615	MCF 10A	10.0	nM	6	hr	397.02	180.42	p-4EBP1	352.80
Gefitinib	MCF 10A	3.16	nM	24	hr	402.15	179.91	p-S6	538.67
Torkinib	MCF 10A	0.422	nM	6	hr	477.98	179.03	p-S6	723.83

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