Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | MCF 10A | 10.0 | nM | 6 | hr | 453.23 | 198.94 | p-S6 | 918.10 | |
| GSK1059615 | MCF 10A | 31.6 | nM | 6 | hr | 411.99 | 186.56 | p-S6 | 785.76 | |
| GSK1059615 | MCF 10A | 3.16 | nM | 6 | hr | 446.31 | 184.25 | p-S6 | 782.26 | |
| Torkinib | MCF 10A | 7.5 | nM | 6 | hr | 516.67 | 184.66 | p-S6 | 775.89 | |
| Torkinib | MCF 10A | 1.78 | nM | 6 | hr | 479.13 | 181.71 | p-S6 | 769.25 | |
| Torkinib | MCF 10A | 0.422 | nM | 6 | hr | 477.98 | 179.03 | p-S6 | 723.83 | |
| Gefitinib | MCF 10A | 316.0 | nM | 24 | hr | 296.12 | 182.11 | p-S6 | 712.92 | |
| GSK1059615 | MCF 10A | 100.0 | nM | 6 | hr | 360.15 | 184.01 | p-S6 | 712.09 | |
| Torkinib | MCF 10A | 31.6 | nM | 24 | hr | 530.47 | 184.23 | p-S6 | 699.60 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 500.23 | 174.95 | p-S6 | 699.38 | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 464.90 | 176.96 | p-S6 | 659.82 | | |
| GSK1059615 | MCF 10A | 1.0 | nM | 6 | hr | 449.62 | 182.84 | p-S6 | 658.02 | |
| Gefitinib | MCF 10A | 100.0 | nM | 24 | hr | 416.72 | 200.10 | p-S6 | 651.75 | |
| Torkinib | MCF 10A | 31.6 | nM | 6 | hr | 483.85 | 173.27 | p-S6 | 648.81 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 375.49 | 156.80 | p-S6 | 644.30 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 374.51 | 155.85 | p-S6 | 642.84 | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 437.21 | 161.21 | p-S6 | 640.43 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 492.19 | 171.34 | p-S6 | 630.46 | | |
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 530.52 | 155.64 | p-S6 | 629.03 | |
| Torkinib | MCF 10A | 562.0 | nM | 6 | hr | 615.73 | 171.90 | p-S6 | 618.02 | |
| Dactolisib | MCF 10A | 10.0 | nM | 6 | hr | 384.28 | 149.95 | p-S6 | 617.51 | |
| Dactolisib | MCF 10A | 1.0 | nM | 6 | hr | 451.01 | 161.00 | p-S6 | 615.55 | |
| Torkinib | MCF 10A | 133.0 | nM | 6 | hr | 548.44 | 168.01 | p-S6 | 609.66 | |
| Gefitinib | MCF 10A | 31.6 | nM | 24 | hr | 408.64 | 195.12 | p-S6 | 597.71 | |
| MK2206 | MCF 10A | 10.0 | uM | 6 | hr | 360.85 | 140.88 | p-S6 | 596.25 | |