Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 250.28 | 91.52 | p-4EBP1 | 117.60 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 247.28 | 82.46 | p-Akt | 41.77 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 262.74 | 87.39 | p-4EBP1 | 128.31 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 173.10 | 49.87 | p-4EBP1 | 76.11 | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 242.63 | 86.72 | p-S6 | 308.51 | | |
| Triciribine | HCC1954 | 316.0 | nM | 6 | hr | 258.48 | 83.20 | p-Akt | 30.56 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 212.56 | 61.42 | p-4EBP1 | 95.54 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 228.04 | 80.31 | p-S6 | 267.13 | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 217.78 | 65.35 | p-4EBP1 | 91.17 | | |
| Triciribine | HCC1954 | 10.0 | nM | 6 | hr | 269.46 | 93.28 | p-4EBP1 | 122.37 | |
| Triciribine | HCC1954 | 316.0 | nM | 6 | hr | 260.64 | 86.03 | p-4EBP1 | 124.51 | |
| Triciribine | HCC1954 | 100.0 | nM | 6 | hr | 247.62 | 90.12 | p-S6 | 371.41 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 214.06 | 73.06 | p-S6 | 229.86 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 271.15 | 84.89 | p-Akt | 24.33 | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 321.42 | 95.62 | p-Akt | 60.23 | | |
| Triciribine | HCC1954 | 10.0 | nM | 6 | hr | 179.66 | 55.22 | p-4EBP1 | 83.92 | |
| Triciribine | HCC1954 | 3.16 | nM | 6 | hr | 275.93 | 96.79 | p-S6 | 400.96 | |
| Triciribine | HCC1954 | 10.0 | nM | 6 | hr | 171.71 | 58.26 | p-S6 | 154.86 | |
| Triciribine | HCC1954 | 100.0 | nM | 6 | hr | 229.88 | 79.67 | p-4EBP1 | 110.74 | |
| Triciribine | HCC1954 | 31.6 | nM | 6 | hr | 257.88 | 87.64 | p-4EBP1 | 119.50 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 235.70 | 85.98 | p-S6 | 488.16 | |
| Triciribine | HCC1954 | 1.0 | uM | 6 | hr | 283.58 | 95.51 | p-S6 | 590.30 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 296.11 | 94.58 | p-S6 | 589.19 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 273.39 | 95.53 | p-S6 | 432.10 | |
| Triciribine | HCC1954 | 100.0 | nM | 6 | hr | 240.14 | 87.78 | p-4EBP1 | 117.61 | |